Abstract
A 9-year-old, male dwarf Angora rabbit (Oryctolagus cuniculus), weighing 1.1 kg, was presented to the referring veterinarian with a history of abdominal pain, anorexia and poor body condition. On physical examination, a solid mass was detected in the abdominal cavity by palpation. No other physical abnormalities were apparent at that time. A complete blood cell count revealed a marked hypochromic macrocytic regenerative anaemia and leucopenia with marked lymphopaenia. Serum biochemical analysis showed a marked hypoproteinaemia with hypoalbuminaemia and a moderate increased blood ureic nitrogen concentration. Histopathological evaluation of the intestinal lesion showed a proliferation of spindle cells with morphological features of neoplastic smooth muscle cells which resulted positive for smooth muscle actin, vimentin, desmin, c-kit and faintly positive for cytokeratin (AE1/AE3). Based on histomorphological and immunohistochemical evaluation, a diagnosis of gastrointestinal stromal tumour (GIST) was made. The latter is considered a tumour originating from primitive mesenchymal cells of gastrointestinal tract with pluripotential differentiation. GISTs have been reported in humans, and in a few domestic animal species such as dogs, horses and ferrets. To our best knowledge, this is the first report describing a gastrointestinal stromal tumour in an Angora rabbit. The clinical outcome of GISTs is considered to be similar to other indolent tumours and sarcomas.
References
Banjerjee M, Lowenstine LJ, Munn RJ (1991) Gastric stromal tumours in two rhesus macaques (Macaca mulatta). Vet Pathol 28:30–36
Del Piero F, Summers BA, Credille KM, Cummings JF, Mandelli G (1996) Gastrointestinal stromal tumours in Equidae. Vet Pathol 33:611
Frost D, Lacosta J, Miettinen M (2001) Gastrointestinal stromal tumours and leiomyomas in the dog: a histopathologic, immunohistochemical, and molecular genetic study of 50 cases. Vet Pathol 40:42–54
Fuijmoto H, Shibutani M, Kuroiwa K, Inoue K, Woo GH, U M, Hirose M (2006) A case report of a spontaneous gastrointestinal stromal tumor (GIST) occurring in a F344 rat. Toxicol Pathol 34:164–167
Girard-Luc A, Prata D, Huet H, Lagadic M, Bernex F (2009) A KIT-positive gastrointestinal stromal tumour in a ferret (Mustela putorius furo). J Vet Diagn Invest 21:915–917
Head KW, Cullen JM, Dubielzig RR, Else RW, Misdorp W, Patnaik AK, Tateyama S, van der Gaag I (2003) Histological classification of tumors of the alimentary system of domestic animals, 2nd series, Vol. 10. Armed Forces Institute of Pathology, Washington
Maas CP, ter Haar G, van der Gaag I, Kirpensteijn J (2007) Reclassification of small intestinal and cecal smooth muscle tumours in 72 dogs: clinical, histologic, and immunohistochemical evaluation. Vet Surg 36:302–313
Orosz Z, Tornóczky T, Sápi Z (2005) Gastrointestinal stromal tumours: a clinicopathologic and immunohistochemical study of 136 cases. Pathol Oncol Res 11:11–21
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Bedin, M., Ratto, A., Cimadomo, V. et al. Case report of a spontaneous c-kit positive gastrointestinal stromal tumour in a dwarf Angora rabbit (Oryctolagus cuniculus). Comp Clin Pathol 20, 681–684 (2011). https://doi.org/10.1007/s00580-011-1222-7
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DOI: https://doi.org/10.1007/s00580-011-1222-7