Abstract
Neoplasia of the gastrointestinal system is uncommon in cats, whereas gastric tumors are exceedingly rare. This article describes the occurrence of gastric leiomyoma in a 3-year-old feline leukemia virus (FeLV)-positive cat. The tumor was accidentally diagnosed in a retrospective postmortem histopathological study in feline immunodeficiency virus- and FeLV-infected euthanized cats. At necropsy, a firm, muscular mass measuring 1.5 × 2.5 cm arising from the cardia extending to the fundus part of the stomach was seen. In histopathological examination, the nonencapsulated tumor mass consisted of spindle cells with large nuclei. No abnormal mitotic division, metastasis, or local invasion was seen resembling the diagnosis of leiomyoma. Helicobacter spp. infection was noted in cytological examination, and mixed infection with Helicobacter heilmannii and Helicobacter felis was confirmed in species-specific polymerase change reaction. To our knowledge, gastric leiomyoma has not been reported previously in cats. The association of Helicobacter spp. and FeLV infection with tumor occurrence is uncertain, but chronic antigenic stimulations could be considered as potential predisposing factors for gastric tumors.
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References
Beck JA, Simpson DS (1999) Surgical treatment of gastric leiomyoma in a dog. Aust Vet J 77:161–163
Bridgeford EC, Marini RP, Feng Y, Parry NM, Rickman B, Fox JG (2008) Gastric Helicobacter species as a cause of feline gastric lymphoma: a viable hypothesis. Vet Immunol Immunopathol 123:106–113
Brodey RS (1966) Alimentary tract neoplasms in the cat: a clinicopathologic survey of 46 cases. Am J Vet Res 27:74–80
Culbertson R, Branam JE, Rosenblatt LS (1983) Esophageal/gastric leiomyoma in the laboratory beagle. J Am Vet Med Assoc 183:1168–1171
Espinosa de los Monteros A, Fernandez A, Millan MY, Rodriguez F, Herraez P, Martin de las Mulas J (1999) Coordinate expression of cytokeratins 7 and 20 in feline and canine carcinomas. Vet Pathol 36:179–190
Finnie JW, Leong AS, Milios J (1995) Multiple piloleiomyomas in a cat. J Comp Pathol 113:201–204
Frost D, Lasota J, Miettinen M (2003) Gastrointestinal stromal tumors and leiomyomas in the dog: a histopathologic, immunohistochemical, and molecular genetic study of 50 cases. Vet Pathol 40:42–54
Gleich S, Hartmann K (2009) Hematology and serum biochemistry of feline immunodeficiency virus-infected and feline leukemia virus-infected cats. J Vet Intern Med 23:552–558
Gualtieri M, Monzeglio MG, Scanziani E (1999) Gastric neoplasia. Vet Clin North Am Small Anim Pract 29:415–440
Hohenhaus AE (2008) Neoplastic disease of the stomach. In: Steiner JM (ed) Small animal gastroenterology. Schültersche Verlagsgesellsschaft mbH & CoKG, Hanover, pp 146–148
Kapatkin AS, Mullen HS, Matthiesen DT, Patnaik AK (1992) Leiomyosarcoma in dogs: 44 cases (1983–1988). J Am Vet Med Assoc 201(7):1077–1079
Kook PH, Wiederkehr D, Makara M, Reusch CE (2009) Megaesophagus secondary to an esophageal leiomyoma and concurrent esophagitis. Schweiz Arch Tierheilkd 151:497–501
Levy JK, Edinboro CH, Glotfelty CS, Dingman PA, West AL, Kirkland-Cady KD (2007) Seroprevalence of Dirofilaria immitis, feline leukemia virus, and feline immunodeficiency virus infection among dogs and cats exported from the 2005 Gulf Coast hurricane disaster area. J Am Med Assoc 231:218–225
Louwerens M, London CA, Pedersen NC, Lyons LA (2005) Feline lymphoma in the post-feline leukemia virus era. J Vet Intern Med 19:329–335
Marks SL (2003) Update on feline gastrointestinal neoplasia. 28th World Small Animal Veterinary Association World Congress Proceedings, Bangkok, Thailand
Meshikhes AW, Al-Khalaf EA, Al-Bahar SH (2004) Gastric leiomyoma. Is there an association with Helicobacter pylori? Saudi Med J 25:1758–1759
Miller MA, Ramos-Vara JA, Dickerson MF, Johnson GC, Pace LW, Kreeger JM, Turnquist SE, Turk JR (2003) Uterine neoplasia in 13 cats. J Vet Diagn Invest 15:515–522
Morris J, Dobson J (2001) Small animal oncology, 1st edn. Blackwell Science Ltd, Oxford, p 69
Patnaik AK, Greene RW (1979) Intravenous leiomyoma of the bladder in a cat. J Am Vet Med Assoc 175:381–383
Simpson KW (2005) Disease of stomach. In: Ettinger SJ, Feldman FC (ed) Textbook of veterinary internal medicine, 6th edn. W.B. Saunders Company, pp 1329–1330
Swalec KM, Smeak DD, Baker AL (1989) Urethral leiomyoma in a cat. J Am Vet Med Assoc 195:961–962
Turk MAM, Gallina AM, Russel TS (1981) Nonhematopoeitic gastrointestinal neoplasia in cats. A retrospective study of 44 cases. Vet Pathol 18:614–620
Wilkinson MJ, Bancroft JD (1997) A to Z pathology, 1st edn. Churchill Livingstone Publishing, New York, pp 151–152
Wilson HM (2008) Feline alimentary lymphoma: demystifying the enigma. Top Companion Anim Med 23:177–184
Wolke RE (1963) Vaginal leiomyoma as a cause of chronic constipation in the cat. J Am Vet Med Assoc 143:1103–1105
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The authors are grateful to Dr. Sookhtanloo and Dr. Eslah for their great help.
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None of the authors of this paper has a financial or personal relationship with other people or organizations that could inappropriately influence or bias the content of the paper.
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Akhtardanesh, B., Saberi, M. & Derakhshanfar, A. Gastric leiomyoma in a domestic shorthair cat. Comp Clin Pathol 20, 531–534 (2011). https://doi.org/10.1007/s00580-010-1162-7
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DOI: https://doi.org/10.1007/s00580-010-1162-7