Skip to main content

Advertisement

SpringerLink
Log in

Immune-mediated hemolytic anemia in a dog with acute monoblastic leukemia

  • Brief Communication
  • Published:
Comparative Clinical Pathology Aims and scope Submit manuscript

Abstract

A 10-year-old, female, mixed breed dog was admitted to the animal hospital with signs of jaundice, pigmenturia, depression, and splenomegaly. Hematology revealed non-regenerative anemia, thrombocytopenia, leukopenia with numerous spherocytes, and a few undifferentiated blasts on a blood smear. A bone marrow examination indicated high M:E ratio with increased number of leukemic cells. Based on cytochemistry and protein electrophoresis, the patient was diagnosed with immune-mediated hemolytic anemia with acute monoblastic leukemia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6

References

  • Balch A, Mackin A (2007) Canine immune-mediated hemolytic anemia: pathophysiology, clinical signs and diagnosis. Compend Cont Educ Pract Vet 29:217–225

    Google Scholar 

  • Dorfman M, Dimski DS (1992) Paraproteinemias in small animal medicine. Compend Cont Educ Pract Vet 14:621–631

    Google Scholar 

  • Eckersall PD (2008) Proteins, proteomics, and the dysproteinemias. In: Kaneko JJ, Harvey JW, Bruss ML (eds) Clinical biochemistry of domestic animals, 6th edn. Academic, San Diego, pp 117–155

    Chapter  Google Scholar 

  • Horgan JE, Roberts BK, Schermerhorn T (2009) Splenectomy as an adjunctive treatment for dogs with immune-mediated hemolytic anemia: ten cases (2003–2006). J Vet Emerg Crit Care 19:254–261

    Article  Google Scholar 

  • Kass L (1982) Leukemia, cytology and cytochemistry. Lippincott, Philadelphia, pp 167–188

    Google Scholar 

  • Klag A, Giger U, Shofer F (1993) Idiopathic immune-mediated hemolytic anemia in dogs: 42 cases (1986–1990). JAVMA 202:783–788

    CAS  PubMed  Google Scholar 

  • Latimer KS, Mahaffey EA, Prasse KW (2003) Duncan and Prasse’s Veterinary laboratory medicine: clinical pathology, 4th edn. Iowa State Press, Ames, pp 21–23

    Google Scholar 

  • Mauro FR, Foa R, Cerretti R, Giannarelli D, Coluzzi S, Mandelli F, Girelli G (2000) Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features. Blood 95:2786–2792

    CAS  PubMed  Google Scholar 

  • Shalm OW, Jain NC, Carroll EJ (1986) Veterinary hematology, 4th edn. Lea & Febiger, Philadelphia, p 1221

    Google Scholar 

  • Stewart A, Feldman B (1993) Immune-mediated hemolytic anemia, part I: an overview. Compend Cont Educ Pract Vet 15:372–381

    Google Scholar 

  • Weinkle TK, Center SA, Randolph JF, Warner KL, Barr SC, Erb HN (2005) Evaluation of prognostic factors, survival rates, and treatment protocols for immune-mediated hemolytic anemia in dogs: 151 cases (1993–2002). JAVMA 226:1869–1880

    Article  PubMed  Google Scholar 

Download references

Acknowledgement

The authors wish to thank Ms. Nuntawan Naowaroj for her assistance in protein electrophoresis.

Author information

Authors and Affiliations

  1. Department of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand

    Kreangsak Prihirunkit & Chaleow Salakij

  2. Department of Physiology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand

    Apassara Choothesa

  3. Muang-Ake Animal Hospital, Lamlukka, Pathumthani, 12130, Thailand

    Apiwat Pisetpaisan

Authors
  1. Kreangsak Prihirunkit
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Apassara Choothesa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chaleow Salakij
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Apiwat Pisetpaisan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kreangsak Prihirunkit.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Prihirunkit, K., Choothesa, A., Salakij, C. et al. Immune-mediated hemolytic anemia in a dog with acute monoblastic leukemia. Comp Clin Pathol 19, 631–634 (2010). https://doi.org/10.1007/s00580-010-1092-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00580-010-1092-4

Keywords

Search

Navigation