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The effects of vitamin C on vitamin K-related clotting factors

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Abstract

The aim of this study was to assess the effects of vitamin C on vitamin K-related clotting factors II, VII, IX and X. Sixty female Wistar rats with a mean weight of 180 ± 20 g were selected, and after a 5-day adaptation period, control blood samples were taken under anaesthesia. The animals were randomly separated into two equal groups: one group received only warfarin for 30 days while the other group received both warfarin and vitamin C. Blood samples were taken at days 15 and 30 to measure vitamin K-related clotting factors, prothrombin time (PT) and activated partial thromboplastin time (APTT). The results showed that the combined administration of vitamin C and warfarin leads to increased coagulation factors II, VII, IX and X and decreased PT and APTT.

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Authors and Affiliations

  1. Department of Clinical Pathology, School of Veterinary Medicine, Islamic Azad University, Kazeroon Branch, Kazeroon, Iran

    Ameneh Khoshvaghti

  2. Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

    S. Nazifi

  3. Department of Physiology, School of Veterinary Medicine, Islamic Azad University, Kazeroon Branch, Kazeroon, Iran

    B. Akbarpour

  4. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

    S. M. Razavi

Authors
  1. Ameneh Khoshvaghti
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  2. S. Nazifi
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  3. B. Akbarpour
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  4. S. M. Razavi
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Correspondence to Ameneh Khoshvaghti.

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Khoshvaghti, A., Nazifi, S., Akbarpour, B. et al. The effects of vitamin C on vitamin K-related clotting factors. Comp Clin Pathol 20, 513–517 (2011). https://doi.org/10.1007/s00580-010-1028-z

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  • DOI: https://doi.org/10.1007/s00580-010-1028-z

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