Involvement of free radicals in animal diseases

Abstract

The balance between free radicals and antioxidants is disrupted in many diseases. This disruption may be attributed to a number of factors such as the inability of the cells to produce sufficient amounts of antioxidants, the nutritional deficiency of minerals or vitamins, and the excess production of reactive oxygen species. The purpose of this article was to explore the involvement of free radicals in the pathogenesis of diseases that affect animals including hepatic diseases, parasitic infestation, mastitis, kidney damage, and carcinogenesis.

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Abbreviations

GSH-Px:

Glutathione peroxidase

GR:

Glutathione reductase

H2O2 :

Hydrogen peroxide

.OH:

Hydroxyl radical

NADPH:

Nicotinamide adenine diphosphate

NO. :

Nitric oxide

ROS:

Reactive oxygen species

O ⋅−2 :

Superoxide anion

SOD:

Superoxide dismutase

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Correspondence to Mahmoud Rushdi Abd Ellah.

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Abd Ellah, M.R. Involvement of free radicals in animal diseases. Comp Clin Pathol 19, 615–619 (2010). https://doi.org/10.1007/s00580-010-1016-3

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Keywords

  • Free radicals
  • Antioxidants
  • Animal