Comparative Clinical Pathology

, Volume 19, Issue 3, pp 235–239 | Cite as

The dextran sulphate sodium (DSS) model of colitis: an overview

  • Livingstone SolomonEmail author
  • Sorsiah Mansor
  • Peter Mallon
  • Eilish Donnelly
  • Margaret Hoper
  • Morris Loughrey
  • Stephen Kirk
  • Keith Gardiner
Review Article


The dextran sulphate sodium model of colitis has demonstrated several correlations with human inflammatory bowel disease and is deemed suitable for investigating pathogenesis, therapeutic options and the dysplasia–adenocarcinoma sequence of inflammatory bowel disease. It is widely applicable to mice, rats, hamsters and guinea pigs. This review explores the features of this model and identifies areas for further research studies.


Dextran sulphate sodium Colitis Inflammatory bowel diseases 



The authors wish to express their gratitude to the Northern Ireland Ileostomy and Internal Pouch Support Group, Daisy Hill Hospital Newry and Royal Victoria Hospital Belfast for funding this research.


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Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Livingstone Solomon
    • 1
    Email author
  • Sorsiah Mansor
    • 2
  • Peter Mallon
    • 1
  • Eilish Donnelly
    • 1
  • Margaret Hoper
    • 1
  • Morris Loughrey
    • 2
  • Stephen Kirk
    • 1
  • Keith Gardiner
    • 1
  1. 1.Institute of Clinical Sciences, Department of SurgeryQueens University of BelfastBelfastUK
  2. 2.Department of PathologyQueens University of BelfastBelfastUK

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