The dextran sulphate sodium (DSS) model of colitis: an overview
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The dextran sulphate sodium model of colitis has demonstrated several correlations with human inflammatory bowel disease and is deemed suitable for investigating pathogenesis, therapeutic options and the dysplasia–adenocarcinoma sequence of inflammatory bowel disease. It is widely applicable to mice, rats, hamsters and guinea pigs. This review explores the features of this model and identifies areas for further research studies.
KeywordsDextran sulphate sodium Colitis Inflammatory bowel diseases
The authors wish to express their gratitude to the Northern Ireland Ileostomy and Internal Pouch Support Group, Daisy Hill Hospital Newry and Royal Victoria Hospital Belfast for funding this research.
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