Comparative Clinical Pathology

, Volume 19, Issue 4, pp 429–431 | Cite as

Thromboelastography in a cat with steroid responsive thrombocytopenia

Brief Communication

Abstract

A Devon Rex cat was presented for bruises, petechie, and ecchymoses. Marked thrombocytopenia was the only primary abnormality noted on initial hematology and other testing. Thromboelastography and clinical signs supported the conclusion that this was a true thrombocytopenia. Use of optical platelet counting to detect large platelets and prostaglandin E1 to prevent platelet aggregation ruled out pseudothrombocytopenia. Exclusion of likely causes of thrombocytopenia and a rapid response to immunosuppressive doses of prednisolone suggested this was an immune-mediated thrombocytopenia. Signs of bleeding returned when the prednisolone dosage was decreased, and the platelet count again increased rapidly to an increased dosage. Thromboelastography showed marked hypocoagulability and may be useful to differentiate true thrombocytopenia from pseudothrombocytopenia, which occurs commonly in cats.

Keywords

TEG Feline Optical Platelet numbers Prostaglandin E1 

References

  1. Bianco D, Armstrong PJ, Washabau RJ (2008) Presumed primary immune-mediated thrombocytopenia in four cats. J Feline Med Surg 10:495–500CrossRefPubMedGoogle Scholar
  2. Chong BH (1995) Diagnosis, treatment and pathophysiology of autoimmune thrombocytopenias. Crit Rev Oncol Hematol 20:271–296CrossRefPubMedGoogle Scholar
  3. Epstein KL, Brainard BM, Loopes MA, Barton MH, Moore JN (2009) Thromboelastography in 26 healthy horses with and without activation by recombinant human tissue factor. J Vet Emerg Crit Care 19:96–101Google Scholar
  4. Jordan HL, Grindem CB, Breitschwerdt EB (1993) Thrombocytopenia in cats: a retrospective study of 41 cases. J Vet Intern Med 7:261–265CrossRefPubMedGoogle Scholar
  5. Kohn B, Linden T, Leibold W (2006) Platelet-bound antibodies detected by a flow cytometric assay in cats with thrombocytopenia. J Feline Med Surg 8:254–260CrossRefPubMedGoogle Scholar
  6. Krisensen AT (2009). Evaluation of haemostasis in cats using thromboelastography (2009). Proceedings 19th ECVIM-CA Congress, Porto Portugal, 170–172Google Scholar
  7. Leclere M, Lavoie JP, Dunn M, Bédard C (2009) Evaluation of a modified thromboelastography assay initiated with recombinant human tissue factor in clinically healthy horses. Vet Clin Path 38:462–466Google Scholar
  8. Lilliehook I, Tvedten H (2009) Validation of the Sysmex XT-2000iV hematology system for dogs, cats, and horses. I. Erythrocytes, platelets, and total leukocyte counts. Vet Clin Pathol 38:163–174CrossRefPubMedGoogle Scholar
  9. Macmillan DC, Sim AK (1970) A comparative study of platelet aggregation in man and laboratory animals. Thromb Diath Haemorrh 24:385–289PubMedGoogle Scholar
  10. Meyers KM, Holmsen H, Seachord CL (1982) Comparative study of platelet dense granule constituents. Am J Physiol 243:54–61Google Scholar
  11. Norman EJ, Barron RC, Nash SA, Clampitt RB (2001) Prevalence of low automated platelet counts in cats: comparison with prevalence of thrombocytopenia based on blood smear estimation. Vet Clin Pathol 30:137–140CrossRefPubMedGoogle Scholar
  12. Sinha AK, Colman RW (1978) Prostaglandin E1 inhibitis platelet aggregation by a pathway independent of adenosine 3', 5'-monophosphate. Science 200:202–203CrossRefPubMedGoogle Scholar
  13. Sinha AK, Colman RW (1983) Cyclic AMP independent inhibition of platelet aggregation by prostaglandin E1 is mediated through factor Xa. Thromb Res 30:553–564CrossRefPubMedGoogle Scholar
  14. Tasker S, Cripps PJ et al (2001) Evaluation of methods of platelet counting in the cat. J Small Anim Pract 42:326–332CrossRefPubMedGoogle Scholar
  15. Tasker S, Mackin AJ et al (1999) Primary immune-mediated thrombocytopenia in a cat. J Small Anim Pract 40:127–131CrossRefPubMedGoogle Scholar
  16. Tvedten H, Johansson P (2009) Feline platelet counting with prostaglandine E1 on the Sysmex XT-2000iV. Vet Clin Path. doi:10.1111/j.1939-165X.2009.00210.x
  17. Weiser MG, Kociba GJ (1984) Platelet concentration and platelet volume distribution in healthy cats. Am J Vet Res 45:518–522PubMedGoogle Scholar
  18. Wiinberg B, Jensen AL, Rojkjaer R, Johannson P, Kjelgaard-Hansen M, Kristensen AT (2005) Validation of human recombinant tissue factor-activated thromboelastography on citrated whole blood from clinically healthy dogs. Vet Clin Pathol 34:389–393CrossRefPubMedGoogle Scholar
  19. Wiinberg B, Jensen AL, Rozanski E, Johansson PI, Kjelgaard-Hansen M, Tranholm M, Kristensen AT (2009) Tissue factor activated thromboelastography correlates to clinical signs of bleeding in dogs. Vet J 179:121–129CrossRefPubMedGoogle Scholar
  20. Wilkins RJ, Hurvitz AI, Hurvitz AI, Dodds-Laffin WJ (1973) Immunologically mediated thrombocytopenia in the dog. J Am Vet Med Assoc 163:277–282PubMedGoogle Scholar
  21. Zelmanovic D, Hetherington EJ (1998) Automated analysis of feline platelets in whole blood, including platelet count, mean platelet volume, and activation state. Vet Clin Pathol 27:2–9CrossRefPubMedGoogle Scholar
  22. Zuckerman L, Cohen E, Woodward JP, Caprini JA (1981) Comparison of thrombelastography with common coagulation tests. Thromb Haemost 46:752–756PubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  1. 1.University Veterinary HospitalSwedish University of Agricultural ScienceUppsalaSweden
  2. 2.Bagarmossen Referral Animal HospitalBagarmossenSweden
  3. 3.Strömsholm Referral Animal HospitalStrömsholmSweden

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