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Evaluation of the resistance of indigenous Iranian cattle to Theileria annulata compared with Holstein cattle by measurement of acute phase proteins

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Abstract

This study was conducted to evaluate the resistance of indigenous cattle against Theileria annulata in comparison with that of Holsteins, through assessment of changes in acute phase proteins. Blood samples were collected from 24 indigenous and 26 Holstein dairy cattle, 2–3 years old, which had become naturally infected with T. annulata. Twenty-five healthy cattle, ten indigenous and 15 Holsteins were selected as a control group. The Theileria-infected group were divided into four subgroups according to their parasitemia rates (<1%, 1–3%, 3–5% and >5%). Measurement of red blood cells (RBCs), packed cell volume (PCV), haemoglobin (Hb), haptoglobin (Hp), serum amyloid A (SAA), ceruloplasmin and fibrinogen were done for all animals using validated methods. Results showed significant differences in RBCs, PCV, Hb and concentrations of Hp, SAA, ceruloplasmin and fibrinogen between healthy cattle and those infected with T. annulata with different parasitemia rates in both breeds (P < 0.05). In both breeds, there was significant negative correlation between parasitemia and RBCs, PCV and Hb (P < 0.05). In contrast, with increasing parasitemia rate, a significant increase in MCV, Hp, SAA, ceruloplasmin and fibrinogen was evident. Iranian indigenous cattle in comparison with Holsteins showed lower parasitemia rate, milder clinical manifestations and significantly lower levels of acute phase proteins including Hp, SAA, ceruloplasmin and fibrinogen (P < 0.05).

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Abbreviations

APP:

Acute phase protein

Hb:

Haemoglobin

Hp:

Haptoglobin

MCV:

Mean corpuscular volume

MCH:

Mean corpuscular haemoglobin

MCHC:

Mean corpuscular haemoglobin concentration

PCV:

Packed cell volume

RBC:

Red blood cell

SAA:

Serum amyloid A

TNF:

Tumour necrosis factor

WBC:

White blood cell

References

  • Bram RA (1983) Tick-borne livestock diseases and their vectors: the global problem. In: Ticks and Tick-borne Diseases, FAO Animal Production and Health Paper. (Food and Agricultural Organization, Rome) 36: 7–11

  • Dhar S, Gautam OP (1979) Observations on anemia in experimentally induced Theileria annulata infection of calves. Indian J Anim Sci 49:511–516

    Google Scholar 

  • Eckersall PD (2004) The time is right for acute phase protein assays. Vet J 168:3–5

    PubMed  CAS  Google Scholar 

  • Feldman BV, Zinkl JG, Jain NC (2000) Schalm, s Veterinary Hematology, 5th edn. Williams &Wilkins, Philadelphia, p 1152

    Google Scholar 

  • Forsyth LMG, Jackson LA, Wilkie G, Sanderson A, Brown CGD, Preston PM (1997) Bovine cells infected in vivo with Theileria annulata express CDllb, the C3bi complement receptor. Vet Res Commun 21:249–263. doi:10.1023/A:1005886725717

    Article  PubMed  CAS  Google Scholar 

  • Glass EJ, Preston PM, Springbett A, Craigmile S, Kirvar E, Wilkie G, Brown CG (2005) Bos taurus and Bos indicus (Sahiwal) calves respond differently to infection with Theileria annulata and produce markedly different levels of acute phase proteins. Int J Parasitol 35:337–347. doi:10.1016/j.ijpara.2004.12.006

    Article  PubMed  CAS  Google Scholar 

  • Glass EJ, Jensen K (2007) Resistance and susceptibility to a protozoan parasite of cattle—gene expression differences in macrophages from different breeds of cattle. Vet Immunol Immunopathol 15(120):20–30. doi:10.1016/j.vetimm.2007.07.013

    Article  CAS  Google Scholar 

  • Glass EJ, Graigmile SC, Springbett A, Preston PM, Kirvar E, Wilkie GM, Eckersall PK, Hall FR, Brown CG (2003) The protozoan parasite Theileria annulata induces a distinct acute phase protein response in cattle that is associated with pathology. Int J Parasitol 33:1409–1418. doi:10.1016/S0020-7519(03)00166-8

    Article  PubMed  CAS  Google Scholar 

  • Gruys E, Obwolo MJ, Toussaint MJM (1994) Diagnostic significance of the major acute phase proteins in veterinary clinical chemistry: a review. Vet Bull 64:1009–1018

    Google Scholar 

  • Gruys E, Toussaint MJM, Niewold TA, Koopmans SJ (2005) Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B 6:1045–1056. doi:10.1631/jzus.2005.B1045

    Article  PubMed  CAS  Google Scholar 

  • Hashemi- Fesharki R (1988) Control of Theileria annulata in Iran. Parasitol Today 4:36–40

    Article  PubMed  CAS  Google Scholar 

  • Hashemi-Fesharki R (1991) Chemotherapeutic value of parvaquone and buparvaquone against Theileria annulata infection of cattle. Res Vet Sci 50:204–207

    PubMed  CAS  Google Scholar 

  • Jain NC (1986) Schalm’s Veterinary Hematology.1st edn., Lea &Febiger., Philadelphia, 20–80

  • Jubb KVF, Kenedy PC, Palmer N (1991) Pathology of domestic animals. 4th edn. Vol 3, Academic, California, 251–255

  • Mehta HK, Sisodia RS, Misraula RS (1988) Clinical and haematological observations in experimentally induced cases of bovine theileriosis. Indian J Anim Sci 58:584–587

    Google Scholar 

  • Minjauw B, McLeod A (2003) Tick-borne diseases and poverty. The impact of ticks and tick-borne diseases on the livelihoods of small-scale and marginal livestock owners in India and eastern and southern Africa. Research report, DFID Animal Health Programme, Center for Tropical Veterinary Medicine, University of Edinburgh, UK

  • Murata H, Shimada N, Yoshioka M (2004) Current research on acute phase proteins in veterinary diagnosis: an overview. Vet J 168:28–40

    Article  PubMed  CAS  Google Scholar 

  • Mwangi EK, Stevenson P, Ndung UJM, Stear MJ, Reid SW, Gettinby G, Murray M (1998) Studies on host resistance to tick infestations among trypanotolerant Bos indicus cattle breeds in east Africa. Ann N Y Acad Sci 849:195–208

    Article  PubMed  CAS  Google Scholar 

  • Omer OH, El-Malik KH, Magzoub M, Mahmoud OM, Haroun EM, Hawas A, Omar HM (2003a) Biochemical profiles in Friesian cattle naturally infected with Theileria annulata in Saudi Arabia. Vet Res Comm 27:15–25

    Article  CAS  Google Scholar 

  • Omer OH, Haroun EM, Mahmoud OM, Abdel-Magied EM, El-Malik KH, Magzoub M (2003b) Parasitological and clinicopathological profiles in Friesian cattle naturally infected with Theileria annulata in Saudi Arabia. J Vet Med B 50:200–203

    Article  CAS  Google Scholar 

  • Radostits OM, Gay CC, Hinchcliff KW, Constable PD (2007) Veterinary Medicine. 10th ed.1529

  • Rayula V, Hafeez MD (1995) Haematological values in cattle infected with Theileria annulata. Indian J Anim Sci 65:1202–1203

    Google Scholar 

  • Sandhu GS, Grewal AS, Singh A, Kondal JK, Singh J, Brar RS (1998) Haematological and biochemical studies in experimental Theileria annulata infection in crossbred calves. Vet Res Comm 22:347–354

    Article  CAS  Google Scholar 

  • Sharma NN (1979) Hematological observations in bovine theileriosis, anaplasmosis and in mixed infections. Indian J Parasitol 3:153–156

    Google Scholar 

  • Shiono H, Yagi Y, Chikayama Y, Miyazaki S, Nakamura I (2003) Oxidative damage and phosphatidylserine expression of red blood cells in cattle experimentally infected with Theileria sergenti. Parasitol Res 89:228–234

    PubMed  Google Scholar 

  • Singh A, Singh J, Grewal AS, Brar RS (2001) Studies on some blood parameters of crossbred calves with experimental Theileria annulata infections. Vet Res Comm 25:289–300

    Article  CAS  Google Scholar 

  • Stockham SL, Kjemtrup AM, Conrad PA, Schmridt DA, Scott MA, Robinson TW, Tyler JW, Johnson GC, Carson CA, Cyddugee P (2000) Theileriosis in a Missouri beef herd caused by Theileria buffeli: case report, herd investigation ultrastructure, phylogenetic analysis and experimental transmission. Vet Pathol 37:11–21

    Article  PubMed  CAS  Google Scholar 

  • Sunderman FW Jr, Nomoto S (1970) Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity. Clin Chem 160:903–907

    Google Scholar 

  • Taylor SM, Hunter AG, Andrew AH, Blowery RW, Oyd H, Eddy RG (1992) Tick and arthropod-borne diseases. In: Bovine medicine, diseases and husbandry of cattle, Blackwell Scientific Publications, Cambridge, 722-757

  • Thrall MA (2004) Veterinary Hematology and Clinical Chemistry. Lippincott Williams and Wilkins, Philadelphia, pp 401–415

    Google Scholar 

  • Uilenberg G (1981) Theileria species of domestic livestock. In: Irvin AD, Cunningham MP, Young AS (eds) Advances in the control of theileriosis. The Hague, Martinus Nijhoff, pp 4–37

    Google Scholar 

  • Young AS (1981) The epidemiology of theileriosis in East Africa. In: Irvin AD, Cunningham MP, Young AS (eds) Advances in the control of theileriosis. The Hague, Martinus Nijhoff, pp 38–55

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, P.O. Box, 1731, Shiraz, 71345, Iran

    S. Nazifi

  2. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

    S. M. Razavi, M. Reiszadeh, Z. Esmailnezhad & F. Hasanshahi

  3. Department of Food Hygiene, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

    M. Ansari-Lari

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  1. S. Nazifi
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  2. S. M. Razavi
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  3. M. Reiszadeh
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  4. Z. Esmailnezhad
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  5. M. Ansari-Lari
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  6. F. Hasanshahi
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Correspondence to S. Nazifi.

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Nazifi, S., Razavi, S.M., Reiszadeh, M. et al. Evaluation of the resistance of indigenous Iranian cattle to Theileria annulata compared with Holstein cattle by measurement of acute phase proteins. Comp Clin Pathol 19, 155–161 (2010). https://doi.org/10.1007/s00580-009-0853-4

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