Abstract
The administration of recombinant human erythropoietin (r-HuEPO) for treatment of anemia in dogs with renal failure is practical in most of veterinary hospitals, but there is a variation in clinical use among them. However, the determination of r-HuEPO in dogs has never been addressed in Thailand. Therefore, the objective of the present study was to evaluate the clinical efficacy of r-HuEPO to recover the hematology in dogs that had developed chronic renal failure-induced anemia at the Chulalongkorn Small Animal Teaching Hospital, Thailand. The medical records of the anemic dogs admitted to the hospital were reviewed only in case of treatment with r-HuEPO during the period from January to November 2006. The hematologic and serum biochemical data pre and post-treatment with r-HuEPO were assessed. The results were found that means of packed cell volume (PCV), red blood cell count, and hemoglobin concentration were significantly different from the values at week 0 after only 1 week of r-HuEPO treatment until week 8 of treatment. Erythrocyte indices indicated normocytic and normochromic. Other parameters were insignificant during treatment. In conclusion, treatment with r-HuEPO stimulated erythrocyte production in dogs with naturally developing anemia of chronic renal failure during 8-week treatment period. PCV reached the target range within 6 weeks of treatment. Exogenous r-HuEPO had no effect on leukocyte, platelet counts, and serum biochemistry in these uremic dogs.
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We would like to thank Veterinary Diagnostic Laboratory and Chulalongkorn Small Animal Teaching Hospital, Faculty of Veterinary Science, Chulalongkorn University, for the hospitality and the great collaboration in this study.
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Assarasakorn, S., Kaewthamasorn, M. & Niwetpathomwat, A. A retrospective study of clinical use of recombinant human erythropoietin for treatment of anemia in dogs with renal failure in Bangkok, Thailand. Comp Clin Pathol 17, 165–170 (2008). https://doi.org/10.1007/s00580-008-0728-0
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DOI: https://doi.org/10.1007/s00580-008-0728-0