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Evaluation of wound contraction and epithelialization after subcutaneous administration of Theranekron® in cows

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Abstract

Ten bulls (age 7 months, weight 302 ± 15 kg) were used in this study. After sterile preparation of skin, a full thickness wound (20 × 20 mm) was created in each bull. The bulls were randomly assigned into two groups: group 1 received 6 ml Theranekron subcutaneously and group 2 penicillin banzatine 10,000 IU/kg IM. These doses were repeated 6 days after initial wounding. At days 0, 3, 6, 10 and 14, digital photographs were taken from the wounds to calculate wound contraction and epithelialization using geometry. Chi-square test was performed for statistical analysis using SPSS 9 for Windows. There was no significant differences in wound contraction between trial groups (P > 0.05) but a statistical difference was seen in epithelialization between groups (P < 0.05). Epithelialization is one of the most important factors in wound healing. According to the results of the present study, Theranekron can significantly stimulate epithelialization in full thickness wounds in cows during the first 14 days of healing.

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Acknowledgment

The authors would like to thank Golpad Company, Tehran, Iran for the financial support of this research.

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Authors and Affiliations

  1. Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, P.O. Box 91775-1793, Mashhad, Iran

    Kamran Sardari & Mehrdad Mohri

  2. School of Veterinary Medicine, Ferdowsi University of Mashhad, P.O. Box 91775-1793, Mashhad, Iran

    Ehsan Galedar Kakhki

Authors
  1. Kamran Sardari
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  2. Ehsan Galedar Kakhki
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  3. Mehrdad Mohri
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Correspondence to Kamran Sardari.

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Sardari, K., Kakhki, E. & Mohri, M. Evaluation of wound contraction and epithelialization after subcutaneous administration of Theranekron® in cows. Comp Clin Pathol 16, 197–200 (2007). https://doi.org/10.1007/s00580-006-0657-8

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  • DOI: https://doi.org/10.1007/s00580-006-0657-8

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