Skip to main content
Log in

Studies on the relationship between haemoglobin, copper, ceruloplasmin, iron, and superoxide dismutase activity in blood of Iranian fat-tailed sheep

  • Short Paper
  • Published:
Comparative Clinical Pathology Aims and scope Submit manuscript

Abstract

The relationship between haemoglobin, copper, ceruloplasmin, iron, and superoxide dismutase (SOD) activity in blood of Iranian fat-tailed sheep was studied. Blood samples were taken from the jugular vein of 128 clinically healthy Iranian fat-tailed sheep grouped according to their age (<6, 6–12, 12–24, 24–36 and >36 months) and sex. Age had a significant effect on blood concentrations of haemoglobin, ceruloplasmin and SOD activity (P<0.05). Sex had no significant effect on blood concentrations of haemoglobin, copper, iron, ceruloplasmin and SOD. There was no significant correlation between the concentrations of haemoglobin, copper, iron, ceruloplasmin and SOD. The identification of regulatory mechanisms of copper metabolism in Iranian fat-tailed sheep will require further investigations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Andrewartha KA, Caple IW (1980) Effects of changes in nutritional copper on erythrocyte superoxide dismutase activity in sheep. Res Vet Sci 28:101–104

    PubMed  Google Scholar 

  • Arthington JD, Corah LR, Blecha F (1996) The effect of molybdenum-induced copper deficiency on acute phase protein concentrations, superoxide dismutase activity, leukocyte numbers, and lymphocyte proliferation in beef heifers inoculated with bovine herpesvirus-1. J Anim Sci 74:211–217

    PubMed  Google Scholar 

  • Blakely BR, Hamilton DL (1985) Ceruloplasmin as an indicator of copper status in cattle and sheep. Can J Comp Med 49:405–408

    PubMed  Google Scholar 

  • Cerone SI, Sansinanea AS, Streitenberger SA, Garcia MC, Auza NJ (1998) The effect of copper deficiency on the peripheral blood cells of cattle. Vet Res Comm 22:47–57

    Article  Google Scholar 

  • Dakka AA, Abdel ATS (1992) Studies on minerals picture in the blood sera of Egyptian sheep. Assiut Vet Med J 28:242–249

    Google Scholar 

  • Disilvestro RA, Marten JT (1990) Effects of inflammation and copper intake on rat liver and erythrocyte cu-zn superoxide dismutase activity levels. J Nutr 120:1223

    PubMed  Google Scholar 

  • Faye B, Ratovonanahary M, Chacornac JP, Soubre P (1995) Metabolic profiles and risks of diseases in camels in temperate conditions. Comp Biochem Physiol 112A:67–73

    Article  Google Scholar 

  • Feldman BV, Zinkl JG, Jain NC (2000) Schalm’s veterinary hematology. Lippincott Williams and Willikins, Philadelphia, pp 117–140

    Google Scholar 

  • Gengelbach GP, Spears JW (1998) Effects of dietary copper and molybdenum on copper status, cytokine production, and humoral immune response of calves. J Dairy Sci 81:3286–3292

    PubMed  Google Scholar 

  • Hecht H (1986) Content of trace elements in muscles and organs of wild and farm animals. Fleischwirtschaft 66:1246–1252

    Google Scholar 

  • Humphries WR, Phillippo M, Young BW, Bremner I (1983) The influence of dietary iron and molybdenum on copper metabolism in calves. Bri J Nutr 49:77–86

    Article  Google Scholar 

  • Jain NC (1986) Schalm’s veterinary hematology. Lea and Febiger, Philadelphia, pp 41–45

    Google Scholar 

  • Jain NC (1993) Essentials of veterinary hematology. Lea and Febiger, Philadelphia, pp 173–175

    Google Scholar 

  • Kaneko JJ (1989) Clinical biochemistry of domestic animals. Academic Press, NewYork, pp 886–891

    Google Scholar 

  • Katunguka-Rwakishaya E, Larkin H, Kelly WR (1985) Some haematological and blood biochemical components in conventionally reared calves. Irish Vet J 39:118–123

    Google Scholar 

  • Kincaid RL, Gay CC, Krieger RI (1986) Relationship of serum and plasma copper and ceruloplasmin concentrations of cattle and the effects of whole blood sample storage. Am J Vet Res 47:1157–1159

    PubMed  Google Scholar 

  • Konstantinova SG, Russanov EM (1988) Effect of pregnancy and fetal development on sheep liver superoxide dismutase activity. Res Vet Sci 45:287–290

    PubMed  Google Scholar 

  • Milne DB (1994) Assessment of copper nutritional status. Clin Chem 40:1479–1484

    PubMed  Google Scholar 

  • Mohri M, Jannatabadi AA, Aslani MR (2005) Studies on haemoglobin polymorphism of two breeds of Iranian sheep and its relationship to concentrations of iron, copper, haemoglobin, haematocrit and RBC number. Vet Res Comm 29:305–312

    Article  Google Scholar 

  • Nazifi S, Saeb M, Alizadeh A (2000) Studies on the relationship between haemoglobin types of adult dromedary camels and the concentrations of haemoglobin, copper, ceruloplasmin and iron. Comp Haematol Int 10:122–125

    Article  Google Scholar 

  • Nazifi S, Saeb M, Khoshvaghti A (2003) Studies on the relationship between haemoglobin types of adult Turkoman horses and the concentrations of haemoglobin, copper, ceruloplasmin and iron. Comp Clin Path 12:53–56

    Article  Google Scholar 

  • Nazifi S, Rategh S (2005) Haemoglobin types and blood concentrations of haemoglobin, copper, ceruloplasmin and iron in adult Caspian miniature horses. Revue Med Vet 156:50–52

    Google Scholar 

  • Okumura M, Asano M, Tagami M (1998) Serum copper and ceruloplasmin activity at the early growing stage in foals. Can J Vet Res 62:122–126

    PubMed  Google Scholar 

  • Puls R (1988) Mineral levels in animal health. Sherpa International, British Cloumbia pp 70–87, 109–116

  • Schorr G (1988) Iron and iron-binding capacity in serum of clinically healthy horses. Tierarzt Praxis 16:163–165

    Google Scholar 

  • Shukla PC, Desai HB, Pande MB (1980) Blood profiles of Russian Merino sheep. Gujarat Agri Univ Res J 6:38–40

    Google Scholar 

  • Smith P, Stubley D, Blackmore DJ (1983) Measurement of superoxide dismutase, diamine oxidase and ceruloplasmin oxidase in the blood of thoroughbreds. Res Vet Sci 35:160–164

    PubMed  Google Scholar 

  • Subba DB, Thakur RP, Rai LB, Kushwaha NP (1996) Normal haematological values of sheep in the Eastern hills of Nepal. Vet Rev Kathmandu 11:21–23

    Google Scholar 

  • Sunderman FWJr, Nomoto S (1970) Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity. Clin Chem 160:903–907

    Google Scholar 

  • Suttle NF, McMurray CH (1983) Use of erythrocyte copper: zinc superoxide dismutase activity and hair or fleece copper concentrations in the diagnosis of hypocuprosis in ruminants. Res Vet Sci 35:47–52

    PubMed  Google Scholar 

  • Tungtrongchitr R, Pongpaew P, Phonrat B, Tungtrongchitr A, Viroonudomphol D, Vudhivai N, Schelp FP (2003) Serum copper, zinc, ceruloplasmin and superoxide dismutase in Thai overweight and obese. J Med Assoc Thai 86:543–551

    PubMed  Google Scholar 

  • Vajdovich P, Gaal T, Szilagyi A, Harnos A (1997) Changes in some red blood cell and clinical laboratory parameters in young and old Beagle dogs. Vet Res Comm 21:463–470

    Article  Google Scholar 

  • Ward JD, Spears JW (1997) Long-term effects of consumption of low-copper diets with or without supplemental molybdenum on copper status, performance, and carcass characteristics of cattle. J Anim Sci 75:3057–3065

    PubMed  Google Scholar 

  • Woolliams JA, Woolliams C, Suttle NF, Jones DG, Wiener G (1986) Studies on lambs from lines genetically selected for low and high copper status. 2. Incidence of hypocuprosis on improved hill pasture. Anim Prod 43:303–317

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Nazifi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nazifi, S., Rowghani, E. & Nikoosefat, Z. Studies on the relationship between haemoglobin, copper, ceruloplasmin, iron, and superoxide dismutase activity in blood of Iranian fat-tailed sheep. Comp Clin Pathol 14, 114–117 (2005). https://doi.org/10.1007/s00580-005-0562-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00580-005-0562-6

Keywords

Navigation