Comparative Clinical Pathology

, Volume 13, Issue 3, pp 95–99 | Cite as

The role of angiogenesis in cancer

  • A. P. HallEmail author
Original Article


Angiogenesis is the term coined to define the process of new blood vessel formation and has been the subject of intense scientific interest since the discovery of vascular endothelial growth factor (VEGF) in 1989. It is necessary for the growth of the organism, tissue repair and reproductive function. However, pathological angiogenesis is now recognised as an essential feature of conditions such as rheumatoid arthritis, diabetic retinopathy and malignant neoplasia. The development of small molecule inhibitors of this process is regarded as an important therapeutic area in the treatment of human cancers and offers potentially long-term treatment, with significantly fewer side effects than traditional chemotherapeutic treatment regimes.


Vascular Endothelial Growth Factor Diabetic Retinopathy Growth Plate Corpus Luteum Endochondral Ossification 
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Copyright information

© Springer-Verlag London Limited 2005

Authors and Affiliations

  1. 1.Safety AssessmentAstraZeneca PharmaceuticalsMacclesfieldUK

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