Abstract
A 5-year-old Iranian fat-tailed sheep was referred to the Veterinary Clinic of Shiraz University in September 2003 with a history of emaciation, fever, decreased appetite, lethargy and cough. Small cutaneous and subcutaneous nodules were palpable, especially under the ribs on both sides of the thorax. Discrete cutaneous plaques and large scabby lesions were also observed. Very large mammary gland lymph nodes were noticed on palpation. Haematological and serum biochemical values were estimated through standard haematological and biochemical techniques. In this case a normocytic–normochromic anaemia, leukocytosis and lymphocytosis were found. The concentrations of blood urea nitrogen (BUN), creatinine, cholesterol and the activities of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) were higher than the values reported for sheep. Necropsy findings revealed that the lymph nodes were affected in most organs. Malignant lymphoma in the kidney, heart, spleen, mammary glands, liver and bone marrow was observed. The histopathological appearance of the affected tissues varied considerably, depending upon the degree of tumour infiltration. According to the history, clinical signs, laboratory findings, necropsy findings and histopathological examination the case was diagnosed as chronic lymphocytic leukaemia and lymphoma.
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References
Anderson LJ, Jarrett WFH (1968) Lymphosarcoma (leukaemia) in cattle, sheep, and pigs in Great Britain. Cancer 22:398–405
Bostock DE, Owen LN (1973) Porcine and ovine lymphosarcoma: a review. J Natl Cancer Inst 50:933–939
Burtis CA, Ashwood ER (1994) Tietz textbook of clinical chemistry, 2nd edn. Saunders, Philadelphia
Duncan JR, Prasse KW, Mahaffey EA (1994) Veterinary laboratory medicine. Clinical pathology, 3rd edn. Iowa State University Press, Ames
Helfand SC, Modiano JF (2000) In: Feldman BF, Zinkl JG, Jain NC (eds) Schalm’s veterinary hematology, 5th edn. Lippincott Williams and Wilkins, Philadelphia, pp 638–641
Jain NC (1986) Schalm’s veterinary hematology. Lea and Febiger, Philadelphia, pp 41–45
Jain NC (1993) Essentials of veterinary hematology. Lea and Febiger, Philadelphia, pp 335–345
Johnstone AC, Manktelow BW (1978) The pathology of spontaneously occurring malignant lymphoma in sheep. Vet Pathol 15:301
Migaki G (1969) Hematopoietic neoplasms of slaughtered animals. In: Lingeman CH, Garner FM (eds) Comparative morphology of haematopoietic neoplasms. National Cancer Institute Monograph 32. US Government Printing Office, Washington, pp 121–151
Ngaria TA (1980) Ovine lymphosarcoma: a case report. Kenya Vet 4:26
Ohtsu Y, Tsutsumi M, Okada K, Ohshima KI (1992) Histopathological study on experimental ovine lymphosarcoma by bovine leukemia virus. J Fac Agric Iwate Univ 20:315–327
Stockham SL, Scott MA (2002) Fundamentals of veterinary clinical pathology, 1st edn. Blackwell, Iowa State Press, Ames, pp 227–251
Watanabe K, Taneichi A, Thutiya Y, Konno H, Niizeki H, Hayasaka K (1994) A case of ovine lymphosarcoma. J Jpn Vet Med Assoc 47:172–174
Webster WM (1966) Neoplasia in food animals with special reference to high incidence in sheep. N Z Vet J 14:203–214
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Nazifi, S., Ghasrodashti, A.R., Badiei, K. et al. Chronic lymphocytic leukaemia and lymphoma in an Iranian fat-tailed sheep: a case report. Comp Clin Path 13, 142–146 (2005). https://doi.org/10.1007/s00580-004-0530-6
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DOI: https://doi.org/10.1007/s00580-004-0530-6