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Subclavian Vein Thrombosis: A Case Report and Review of the Literature

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International Journal of Angiology

Abstract

Described herein is the case of a 55-year-old woman who was admitted to our hospital because of neck discomfort and left-arm edema. Our patient was diagnosed to have primary left subclavian vein thrombosis. The prevalence of hypercoagulable states in patients with upper-extremity, idiopathic, deep-vein thrombosis is discussed and reviewed.

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References

  1. MC Horattas DJ Wright AH Fenton DM Evans MA Oddi RW Kamienski EF Shields (1988) ArticleTitleChanging concepts of deep venous thrombosis of the upper extremity: Report of a series and review of the literature Surgery 104 561–567 Occurrence Handle1:STN:280:BieA383gs1A%3D Occurrence Handle3046028

    CAS  PubMed  Google Scholar 

  2. FR Franco HP Reitsma (2001) ArticleTitleGenetic risk factors of venous thrombosis Hum Genetics 109 369–384 Occurrence Handle10.1007/s004390100593 Occurrence Handle1:CAS:528:DC%2BD3MXnvFeitb0%3D

    Article  CAS  Google Scholar 

  3. ED Sutherland CI Weitz HA Liebman (2003) ArticleTitleThromboembolic complications of cancer: Epidemiology, pathogenesis, diagnosis, and treatment Am J Hematol 72 43–52 Occurrence Handle10.1002/ajh.10263 Occurrence Handle12508268

    Article  PubMed  Google Scholar 

  4. U Seligsohn A Lubetsky (2001) ArticleTitleGenetic susceptibility to venous thrombosis N Engl J Med 344 1222–1231 Occurrence Handle10.1056/NEJM200104193441607 Occurrence Handle1:CAS:528:DC%2BD3MXjsV2ms7o%3D Occurrence Handle11309638

    Article  CAS  PubMed  Google Scholar 

  5. SM Prescott G Tikoff (1979) ArticleTitleDeep vein thrombosis of the upper extremity: A reappraisal Circulation 59 350–359 Occurrence Handle1:STN:280:CSaD1cvltVU%3D Occurrence Handle759002

    CAS  PubMed  Google Scholar 

  6. ESR Hughes (1949) ArticleTitleVenous ostruction in the upper extremity (Paget-Schroetter’s syndrome) Int Abstr Surg 88 89–127

    Google Scholar 

  7. RG Makhoul HI Machleder (1992) ArticleTitleDevelopmental anomalies at the thoracic outlet: An analysis of 200 consecutive cases J Vase Surg 16 723–732 Occurrence Handle10.1067/mva.1992.41523

    Article  Google Scholar 

  8. M Mukai H Hanaue H Kubo K Tobita T Sakakibara K Mazutani T Fujimoto (1993) ArticleTitleA case of primary subclavian venous thrombosis in a basketball player J Jpn Surg Assoc 54 1235–1239

    Google Scholar 

  9. A Girolami P Prandoni E Zanon P Bagatella B Girolami (1999) ArticleTitleVenous thromboses of upper limbs are more frequently associated with occult cancer as compared with those of lower limbs Blood Coag Fibrinol 10 455–457 Occurrence Handle1:STN:280:DC%2BD3c7gtVCisg%3D%3D

    CAS  Google Scholar 

  10. K Green R Silverstein (1996) ArticleTitleHypercoagulability in cancer Hematol Oncol Clin North Am 10 499–530 Occurrence Handle1:STN:280:BymB1Mrms1M%3D Occurrence Handle8707766

    CAS  PubMed  Google Scholar 

  11. R Hoffman B Brenner (2001) ArticleTitleCancer and thrombosis revisited Blood Rev 15 61–67 Occurrence Handle10.1054/blre.2001.0149 Occurrence Handle1:STN:280:DC%2BD3MzkslWrsw%3D%3D Occurrence Handle11409906

    Article  CAS  PubMed  Google Scholar 

  12. YA Lee (2002) ArticleTitleCancer and thromboembolic disease: Pathogenic mechanisms Cancer Treatment Rev 28 137–140 Occurrence Handle10.1016/S0305-7372(02)00044-0 Occurrence Handle1:CAS:528:DC%2BD38XosVSmsL0%3D

    Article  CAS  Google Scholar 

  13. M Ruggeri G Castaman A Tosetto F Rodeghiero (1997) ArticleTitleLow prevalence of thrombophilic coagulation defects in patients with deep vein thrombosis of the upper limbs Blood Coag Fibrinol 8 191–194 Occurrence Handle1:STN:280:ByiA3cbmtVE%3D

    CAS  Google Scholar 

  14. I Martinelli M Cattaneo D Panzeri E Taioli PM Mannucci (1997) ArticleTitleRisk factors for deep venous thrombosis of the upper extremities Ann Intern Med 126 707–711 Occurrence Handle1:STN:280:ByiB28jkvVU%3D Occurrence Handle9139557

    CAS  PubMed  Google Scholar 

  15. P Prandoni P Polistena E Bernardi et al. (1997) ArticleTitleUpper-extremity deep vein thrombosis: Risk factors, diagnosis and complications Arch Intern Med 157 57–62 Occurrence Handle10.1001/archinte.157.1.57 Occurrence Handle1:STN:280:ByiC2cbitlc%3D Occurrence Handle8996041

    Article  CAS  PubMed  Google Scholar 

  16. E Heron O Lozinguez M Alhenc-Gelas J Emmerich JN Fiessinger (2000) ArticleTitleHypercoagulable states in primary upper-extremity deep vein thrombosis Arch Intern Med 160 382–386 Occurrence Handle10.1001/archinte.160.3.382 Occurrence Handle1:STN:280:DC%2BD3c7jt1aktw%3D%3D Occurrence Handle10668841

    Article  CAS  PubMed  Google Scholar 

  17. FW Leebeek NA Stadhouders D Stein Particlevan EB Gomez-Garcia MC Kappers–Klunne (2001) ArticleTitleHypercoagulability states in upper-extremity deep venous thrombosis Am J Hematol 67 15–19 Occurrence Handle10.1002/ajh.1070 Occurrence Handle1:CAS:528:DC%2BD3MXjtFGmtLc%3D Occurrence Handle11279652

    Article  CAS  PubMed  Google Scholar 

  18. SW Poort FR Resendaal PH Reitsma RM Bertina (1996) ArticleTitleA common genetic variation in the 3′–untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis Blood 88 3698–3703 Occurrence Handle1:CAS:528:DyaK28XntVahsLg%3D Occurrence Handle8916933

    CAS  PubMed  Google Scholar 

  19. M Cattaneo V Chantarangkul E Taioli JH Santos L Tagliabue (1999) ArticleTitleThe G20210 A mutation of the prothrombin gene in patients with previous first episodes of deep-vein thrombosis: Prevalence and association with factor V G1691A, methylenetetrahydrofolate reductase C677T and plasma prothrombin levels Thromb Res 93 1–8 Occurrence Handle10.1016/S0049-3848(98)00136-4 Occurrence Handle1:CAS:528:DyaK1cXotVaqsbk%3D Occurrence Handle10065893

    Article  CAS  PubMed  Google Scholar 

  20. S Eichinger E Minar I Pabinger C Bialonczyk M Stain C Mannhalter A Stumpflen B Schneider K Lechner PA Kyrle (1999) ArticleTitleThe risk of early recurrent venous thromboembolism after oral anticoagulation therapy in patients with the G20210A transition in the prothrombin gene Thromb Haemost 81 14–17 Occurrence Handle1:CAS:528:DyaK1MXhvVaqt7o%3D Occurrence Handle10348706

    CAS  PubMed  Google Scholar 

  21. C Kearon M Gent J Hirsh et al. (1999) ArticleTitleA comparison of three months of coagulation with extended anticoagulation for a first episode of idiopathic thromboembolism N Engl J Med 340 901–907 Occurrence Handle10.1056/NEJM199903253401201 Occurrence Handle1:CAS:528:DyaK1MXit1aitb0%3D Occurrence Handle10089183

    Article  CAS  PubMed  Google Scholar 

  22. AWA Lensing MH Prins (1999) ArticleTitleRecurrent deep vein thrombosis and two coagulation factor gene mutations: Quo vadis? Thromb Haemost 82 1564–1566 Occurrence Handle1:CAS:528:DyaK1MXotVehsb8%3D Occurrence Handle10613635

    CAS  PubMed  Google Scholar 

  23. P Lindmarker S Schulman M Stein-Linder B Wiman N Egberg H Johnsson (1999) ArticleTitleThe risk of recurrent venous thromboembolism in carriers and non-carriers of the G2691A allele in the coagulation factor V gene and the G20210A allele in the prothrombin gene Thromb Haemost 81 684–689 Occurrence Handle1:CAS:528:DyaK1MXjtFOgurs%3D Occurrence Handle10365737

    CAS  PubMed  Google Scholar 

  24. M Margaglione G D’Andrea D Colaizzo G Cappucci A Popolo Particledel V Brancaccio A Ciampa E Grandone G Di Minno (1999) ArticleTitleCoexistence of factor V Leiden and factor II A20210 mutation and recurrent venous thromboembolism Thromb Haemost 82 1583–1587 Occurrence Handle1:CAS:528:DyaK1MXotVehsbo%3D Occurrence Handle10613638

    CAS  PubMed  Google Scholar 

  25. JS Miles JP Miletich SZ Goldhaber CH Hennekens PM Ridker (2001) ArticleTitleG20210A mutation in the prothrombin gene and the risk of recurrent venous thromboembolism J Am Coll Cardiol 37 215–218 Occurrence Handle10.1016/S0735-1097(00)01080-9 Occurrence Handle1:CAS:528:DC%2BD3MXptVKisg%3D%3D Occurrence Handle11153741

    Article  CAS  PubMed  Google Scholar 

  26. P Frosst BJ Blom R Milos et al. (1995) ArticleTitleA candidate genetic risk factor for vascular disease: A common mutation in the methylenetetrahydrofolate reductase Nat Genetics 10 111–113 Occurrence Handle1:CAS:528:DyaK2MXlsVymt78%3D

    CAS  Google Scholar 

  27. M Cottaneo MY Tsai P Bucciarelli E Taioli ML Zighetti M Bignell PM Mannucci (1997) ArticleTitleA common mutation in the methylenetetrahydrofolate reductase gene (C677 T) increases the risk of deep vein thrombosis in patients with mutant factor V (factor V:Q506) Arterioscl Thromb Vasc Biol 17 1662–1666 Occurrence Handle9327760

    PubMed  Google Scholar 

  28. K Brown R Luddington T Baglin (1998) ArticleTitleEffect of MTHFRC677T variant on risk of venous thromboembolism: Interaction with factor V Leiden and prothrombin (F2G20210 A) mutations Br J Haematol 103 42–44 Occurrence Handle10.1046/j.1365-2141.1998.00935.x Occurrence Handle1:CAS:528:DyaK1cXnt1antb4%3D Occurrence Handle9792287

    Article  CAS  PubMed  Google Scholar 

  29. LA Kluijtmans M Heijer Particleden PH Reitsma SG Heil HJ Blom FR Rosendaal (1998) ArticleTitleThermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep vein thrombosis Thromb Haemost 79 254–258 Occurrence Handle1:CAS:528:DyaK1cXhtVeju7o%3D Occurrence Handle9493571

    CAS  PubMed  Google Scholar 

  30. O Salomon DM Steinberg A Zivelin et al. (1999) ArticleTitleSingle and combined prothrombin factors in patients with idiopathic: Prevalence and risk assessment Arterioscl Thromb Vasc Biol 19 511–518 Occurrence Handle1:STN:280:DyaK1M7nsVSquw%3D%3D Occurrence Handle10073951

    CAS  PubMed  Google Scholar 

  31. VH Joffe ZS Goldhaber (2002) ArticleTitleUpper-extremity deep vein thrombosis Circulation 106 1874–1880 Occurrence Handle10.1161/01.CIR.0000031705.57473.1C Occurrence Handle12356644

    Article  PubMed  Google Scholar 

  32. GG Hartnell LA Hughes JP Finn HE Longmaid SuffixIII (1995) ArticleTitleMagnetic resonance angiography of the central chest veins: A new gold standard? Chest 107 1053–1057 Occurrence Handle1:STN:280:ByqB38%2Fgs1c%3D Occurrence Handle7705116

    CAS  PubMed  Google Scholar 

  33. MP Ridker ZS Goldhaber E Danielson et al. (2003) ArticleTitleInvestigators for the Prevent Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism N Engl J Med 348 1425–1434 Occurrence Handle10.1056/NEJMoa035029 Occurrence Handle1:CAS:528:DC%2BD3sXivVChu70%3D Occurrence Handle12601075

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Moses Elisaf M.D., F.R.S.H., F.I.C.A..

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Miltiadous, G., Liamis, G., Metafratzi, Z. et al. Subclavian Vein Thrombosis: A Case Report and Review of the Literature. International Journal of Angiology 13, 45–48 (2004). https://doi.org/10.1007/s00547-004-1035-5

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  • DOI: https://doi.org/10.1007/s00547-004-1035-5

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