Abstract
A catheter sensor system composed of a tube flow sensor with a medical basket forceps and an optical fiberscope was systemized for in-situ measurements in the airway in the lung system. The tube flow sensor was produced by assembling the sensor film containing two heaters onto the tube surface, and the basket forceps was installed into the inside space of the tube sensor. The assembled tube flow sensor with the basket forceps was inserted into the tube and was fixed at the center of the tube by expanding the basket. The flow detection characteristics of the tube flow sensor were experimentally evaluated. A calibration equation based on King’s law was derived from the sensor output vs. flow velocity curve, and a sufficiently short response time of 60 ms was obtained for the breathing measurements in a rabbit and a person. Finally, the tube flow sensor with the basket forceps and the optical fiberscope was systemized into a single tube with the diameter of 5.0 mm for in-situ measurements in the airway. The developed system successfully detected both a breathing airflow waveform and an optical image inside the airway in the rabbit.
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References
Chatzipirpiridis G, Gervasoni S, Berlinger F, Blaž S, Ergeneman O, Pané S, Nelson BJ (2015) Miniaturized magnetic force sensor on a catheter tip. In: Technical digest the 18th international conference on solid-state sensors and actuators, Anchorage, Alaska, June, pp 1727–1730.
Choi W, Rubtsov V, Kim CJ (2011) Pneumatically deployed net system for endoscopic removal of foreign object. In: Proc. micro electro mechanical systems conference, Cancun, Mexico, pp 17–20.
Chong C, Isamoto K, Toshiyoshi H (2006) Optically modulated MEMS scanning endoscope. IEEE Photonics Technol Lett 18(1):133–135
Gianchandani YB, Tabata O, Zappe H (2008) Comprehensive microsystems. Elsevier B.V., Amsterdam 2–3
Goto S, Matsunaga T, Totsu K, Makishi W, Esashi M, Haga Y (2005) Photolithography on cylindrical substrates for realization of high-functional tube-shaped micro-tools. In: Proc. 22nd sensor symposium, pp 112–115.
Harada N, Hasegawa Y, Ono R, Matsushima M, Kawabe T, Shikida M (2017) Characterization of basket-forceps-type micro-flow-sensor for breathing measurements in small airway. Microsyst Technol 23(12):5397–5406
Hasegawa Y, Kawaoka H, Yamada T, Matsushima M, Kawabe T, Shikida M (2017) Respiration and heartbeat signal detection from airflow at airway in rat by catheter flow sensor with tmeparature compensation function. J Micromech Microeng 27:125016 (11pp)
Katsumata T, Haga Y, Minami K, Esashi M (2000) Micromachined 125 μm diameter ultra miniature fiber-optic pressure sensor for catheter. Trans IEE Jpn 120-E 2:58–63
Keulemans G, Ceyssens F, Puers R(2013) Absolute fiber-optic pressure sensing for high-temperature applications using white light interferometry. In: Technical digest The 17th international conference on solid-state sensors and actuators, Barcelona, Spain, June, pp 2325–2328.
King LV (1914) “On the convection of heat from small cylinders in a stream of fluid: determination of the convection constants of small platinum wires with applications to hot-wire anemometry”, Philosophical Transactions of the Royal Society of London. Ser A Contain Papers Math Phys Character 214:373–432
Kusuda S, Sawano S, Konishi S (2007) Fluid-resistive bending sensor having perfect compatibility with flexible pneumatic balloon actuator. In: Proc. micro electro mechanical systems conference, Kobe, Japan, pp 615–618.
Li C, Wu PM, Prince SJ, Wu Z, Chakraborti S, Ahn CH, Hartings JA, Narayan RK (2013) Multifunctional lab-on-a-tube (LOT) probe for simultaneous neurochemical and electrophysiological activity measurements. In: Technical digest the 17th international conference on solid-state sensors and actuators, Barcelona, Spain, June, pp 880–883.
Maeda Y, Okihara C, Hasegawa Y, Taniguchi K, Matsushima M, Kawabe T, Shikida M(2019)s Micro-machined catheter flow sensor systemization for in-situ breathing and optical imaging measurements in bronchus region in lung system. In: Tech. Dig. 20th International conference on solid-state sensors, actuators and microsystems, Berlin, Germany, Jun., pp 2247–2250.
Mimoun B, van der Horst A, Dekker R, van der Voort D, van der Horst A, Rutten M, van de Vosse F (2012) Thermal flow sensors on flexible substrates for minimally invasive medical instruments. Proc. IEEE Sensors 2012, Taipei, Taiwan, Oct., pp 2192–2195.
Muller RS, Howe RT, Senturia SD, Smith RL, White RM (1991) Microsensors. IEEE Press, New York
Okihara C, Hasegawa Y, Shikida M, Matsushima M, Kawabe T ((2016)) Development of cylinder hollow structure with flow sensor by film transfer technology. In: Proc. IEEE sensors 2016, Orland, USA Oct.-Nov., A-6-213.
Okihara C, Hasegawa Y, Matsushima M, Kawabe T, Shikida M (2018) Development of tube flow sensor by using film transfer technology and its application to in-situ breathing and surface image evaluation in airways. Microsyst Technol 24(8):3417–3424
Ristic L (1994) Sensor technology and devices. Artch House Inc, Norwood
Senturia SD (2001) Microsystem design. Kluwer Academic Publishers, Boston / Dordrecht / London
Shikida M, Naito J, Yokota T, Kawabe T, Hayashi Y, Sato K (2009) A catheter-type flow sensor for measurement of aspirated- and inspired-air characteristics in bronchial region. J Micromech Microeng 19:105027 (9pp)
Shikida M, Matsuyama T, Yamada T, Matsushima M, Kawabe T (2017) Development of implantable catheter flow sensor into inside of bronchi for laboratory animal. Microsyst Technol 23(1):175–185
Takahata K, DeHennis A, Wise KD, Gianchandani YB(2004) A wireless microsensor for monitoring flow and pressure in a blood vessel utilizing dual-inductor antenna stent and two pressure sensors. In: Proc. micro electro mechanical systems conference, Maastricht, The Netherlands, pp 216–219.
Watanabe Y, Maeda M, Yaji N, Nakamura R, Iseki H, Yamato M, Okano T, Hori S, Konishi S (2007) Small, soft, and safe microactuator for retinal pigment epithelium transplantation. In: Proc. micro electro mechanical systems conference, Kobe, Japan, pp 659–662.
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This work was supported by JSPS KAKENHI Grant Number JP18K04912, Hiroshima City University Grant for Special Academic Research, and a research grant from The Uehara Memorial Foundation.
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Maeda, Y., Okihara, C., Hasegawa, Y. et al. Catheter sensor system for in-situ breathing and optical imaging measurements at airway in inside of lung. Microsyst Technol 26, 3705–3713 (2020). https://doi.org/10.1007/s00542-020-04843-4
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DOI: https://doi.org/10.1007/s00542-020-04843-4