Paper-based resistive heater with accurate closed-loop temperature control for microfluidics paper-based analytical devices

  • Saeed Atabakhsh
  • Zahra Latifi Namin
  • Shahin Jafarabadi Ashtiani
Technical Paper
  • 60 Downloads

Abstract

Accurate temperature controlling system is essential for temperature-sensitive applications of microfluidics technology. In this paper, for the first time, we implemented a low-cost temperature controlling system on paper to be used in paper-based microfluidics. A resistive heater was fabricated by screen-printing of conductive electric paint on paper substrate. The temperature was measured by a non-contact temperature sensor to suppress the effect of contact sensors’ thermal mass on the measured temperature. By utilizing PID controller in a closed-loop system, the accuracy of temperature is below 0.22 °C which is suitable for biological temperature-sensitive applications. A microfluidics paper-based analytical device (µPAD) is fabricated by screen-printing on filter paper and attached to the heater to be used as device under test. The fabrication and implementation procedures of the whole system including the heater, the temperature controller and the µPAD are very low-cost, fast and simple. The operation of the fabricated heater and the temperature controlling system were validated by a temperature-sensitive colorimetric test of cholesterol.

Notes

Acknowledgements

We thank Professor Shams Mohajerzadeh from Nano Electronic Lab at the University of Tehran for providing us with the SEM images.

References

  1. Abadian A, Jafarabadi-Ashtiani S (2014) Paper-based digital microfluidics. Microfluid Nanofluid 16:989–995CrossRefGoogle Scholar
  2. Abadian A, Sepehri Manesh S, Jafarabadi Ashtiani S (2017) Hybrid paper-based microfluidics: combination of paper-based analytical device (µPAD) and digital microfluidics (DMF) on a single substrate. Microfluid Nanofluid 21:65.  https://doi.org/10.1007/s10404-017-1899-2 CrossRefGoogle Scholar
  3. Bruzewicz DA, Reches M, Whitesides GM (2008) Low-cost printing of poly (dimethylsiloxane) barriers to define microchannels in paper. Anal Chem 80:3387–3392CrossRefGoogle Scholar
  4. Busuioc C, Evanghelidis A, Galatanu A, Enculescu I (2016) Direct and contactless electrical control of temperature of paper and textile foldable substrates using electrospun metallic-web transparent electrodes. Sci Rep 6:34584CrossRefGoogle Scholar
  5. Chang Y-H, Lee G-B, Huang F-C, Chen Y-Y, Lin J-L (2006) Integrated polymerase chain reaction chips utilizing digital microfluidics. Biomed Microdevice 8:215–225CrossRefGoogle Scholar
  6. Chauhan N, Pundir C (2011) Co-immobilization of cholesterol esterase, cholesterol oxidase and peroxidase on PVC strip for serum cholesterol determination. Anal Methods 3:1360–1365CrossRefGoogle Scholar
  7. Cheng CM et al (2010) Paper-based ELISA. Angew Chem Int Edn 49:4771–4774CrossRefGoogle Scholar
  8. Delaney JL, Hogan CF, Tian J, Shen W (2011) Electrogenerated chemiluminescence detection in paper-based microfluidic sensors. Anal Chem 83:1300–1306CrossRefGoogle Scholar
  9. Esquivel J, Del Campo F, de la Fuente JG, Rojas S, Sabate N (2014) Microfluidic fuel cells on paper: meeting the power needs of next generation lateral flow devices. Energy Environ Sci 7:1744–1749CrossRefGoogle Scholar
  10. Estes MD, Yang J, Duane B, Smith S, Brooks C, Nordquist A, Zenhausern F (2012) Optimization of multiplexed PCR on an integrated microfluidic forensic platform for rapid DNA analysis. Analyst 137:5510–5519CrossRefGoogle Scholar
  11. Fan Y, Liu S, Gao K, Zhang Y (2018) Fully enclosed paper-based microfluidic devices using bio-compatible adhesive seals. Microsyst Technol 24:1783–1787CrossRefGoogle Scholar
  12. Fang X, Guan M, Kong J (2015) Rapid nucleic acid detection of Zaire ebolavirus on paper fluidics. RSC Adv 5:64614–64616.  https://doi.org/10.1039/C5RA09430E CrossRefGoogle Scholar
  13. Gilchrist KH, Giovangrandi L, Whittington RH, Kovacs GT (2005) Sensitivity of cell-based biosensors to environmental variables. Biosens Bioelectron 20:1397–1406CrossRefGoogle Scholar
  14. Hagan KA, Reedy CR, Uchimoto ML, Basu D, Engel DA, Landers JP (2011) An integrated, valveless system for microfluidic purification and reverse transcription-PCR amplification of RNA for detection of infectious agents. Lab Chip 11:957–961CrossRefGoogle Scholar
  15. Hsu W-T et al (2011) Integration of fiber optic-particle plasmon resonance biosensor with microfluidic chip. Anal Chim Acta 697:75–82CrossRefGoogle Scholar
  16. Huang C-J, Chen Y-H, Wang C-H, Chou T-C, Lee G-B (2007) Integrated microfluidic systems for automatic glucose sensing and insulin injection. Sens Actuators B Chem 122:461–468CrossRefGoogle Scholar
  17. Huang M, Fan S, Xing W, Liu C (2010) Microfluidic cell culture system studies and computational fluid dynamics. Math Comput Model 52:2036–2042CrossRefGoogle Scholar
  18. Ibrahim D (2002) Microcontroller-based temperature monitoring and control, 1st edn. Newnes, Oxford, pp 183–190Google Scholar
  19. Kalish B, Tsutsui H (2014) Patterned adhesive enables construction of nonplanar three-dimensional paper microfluidic circuits. Lab Chip 14:4354–4361CrossRefGoogle Scholar
  20. Kim J-W, Yoshida K, Kouda K, Yokota S (2009) A flexible electro-rheological microvalve (FERV) based on SU-8 cantilever structures and its application to microactuators. Sens Actuators A 156:366–372CrossRefGoogle Scholar
  21. Kohl M, Abdel-Khalik S, Jeter S, Sadowski D (2005) A microfluidic experimental platform with internal pressure measurements. Sens Actuators A 118:212–221CrossRefGoogle Scholar
  22. Li X, Ballerini DR, Shen W (2012) A perspective on paper-based microfluidics: current status and future trends. Biomicrofluidics 6:011301CrossRefGoogle Scholar
  23. Liu C, Mauk MG, Hart R, Qiu X, Bau HH (2011) A self-heating cartridge for molecular diagnostics. Lab Chip 11:2686–2692CrossRefGoogle Scholar
  24. Martinez AW, Phillips ST, Butte MJ, Whitesides GM (2007) Patterned paper as a platform for inexpensive, low-volume, portable bioassays. Angew Chem Int Ed 46:1318–1320CrossRefGoogle Scholar
  25. Mondal S, Venkataraman V (2007) Novel fluorescence detection technique for non-contact temperature sensing in microchip PCR. J Biochem Biophys Methods 70:773–777CrossRefGoogle Scholar
  26. Murray I, Walker G, Bereman MS (2016) Improving the analytical performance and versatility of paper spray mass spectrometry via paper microfluidics. AnalystGoogle Scholar
  27. Neuzil P, Pipper J, Hsieh TM (2006) Disposable real-time microPCR device: lab-on-a-chip at a low cost. Mol BioSyst 2:292–298CrossRefGoogle Scholar
  28. Ohlander A et al (2013) Genotyping of single nucleotide polymorphisms by melting curve analysis using thin film semi-transparent heaters integrated in a lab-on-foil system. Lab Chip 13:2075–2082CrossRefGoogle Scholar
  29. Pal D, Venkataraman V (2002) A portable battery-operated chip thermocycler based on induction heating. Sens Actuators A 102:151–156CrossRefGoogle Scholar
  30. Privorotskaya N et al (2010) Rapid thermal lysis of cells using silicon–diamond microcantilever heaters. Lab Chip 10:1135–1141CrossRefGoogle Scholar
  31. Shaw KJ, Docker PT, Yelland JV, Dyer CE, Greenman J, Greenway GM, Haswell SJ (2010) Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling. Lab Chip 10:1725–1728CrossRefGoogle Scholar
  32. Sieben VJ, Debes-Marun CS, Pilarski LM, Backhouse CJ (2008) An integrated microfluidic chip for chromosome enumeration using fluorescence in situ hybridization. Lab Chip 8:2151–2156CrossRefGoogle Scholar
  33. Siegel AC, Phillips ST, Wiley BJ, Whitesides GM (2009) Thin, lightweight, foldable thermochromic displays on paper. Lab Chip 9:2775–2781CrossRefGoogle Scholar
  34. Thom NK, Yeung K, Pillion MB, Phillips ST (2012) “Fluidic batteries” as low-cost sources of power in paper-based microfluidic devices. Lab Chip 12:1768–1770CrossRefGoogle Scholar
  35. Yamamoto T, Fujii T, Nojima T (2002) PDMS-glass hybrid microreactor array with embedded temperature control device. Application to cell-free protein synthesis. Lab Chip 2:197–202CrossRefGoogle Scholar
  36. Yu I, Yu Y, Chen L, Fan S, Chou H, Yang J (2014) A portable microfluidic device for the rapid diagnosis of cancer metastatic potential which is programmable for temperature and CO2. Lab Chip 14:3621–3628CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Electrical and Computer Engineering, College of EngineeringUniversity of TehranTehranIran

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