Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles

Abstract

This paper describes fabrication of a new hemocompatible, magnetic nanoparticles based on magnetite and naturally occurring chitosan, potentially applicable as biomaterials to nanobiomedicine. We fabricated carboxy-functionalized magnetite–chitosan (Fe3O4–CS–BTCDA) nanocomposite particles by a simple two-stage protocol. Magnetite–chitosan (Fe3O4–CS) nanocomposite particles were first prepared via in situ chemical coprecipitation reactions using Fe2+ and Fe3+ salts in an alkaline aqueous solution of CS. Fe3O4–CS nanocomposite particles were then reacted with butanetetracarboxylic dianhydride (BTCDA) to obtain the Fe3O4–CS–BTCDA nanocomposite particles dispersible under physiological conditions. The obtained nanoparticles are superparamagnetic. The hemolytic activity of the Fe3O4–CS–BTCDA nanocomposite particles is very low and essential for practical bio-related applications.

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Acknowledgements

The authors thank Mr. Nobuaki Kutsuzawa and Dr. Osamu Ishii of Yamagata University for instruction on the magnetic measurements, and Dr. Shigekazu Yano of Yamagata University for his kind assistance on the hemocompatibility analysis. Md. Abdur Rahman also acknowledges the financial support from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

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Correspondence to Bungo Ochiai.

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Rahman, M.A., Ochiai, B. Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles. Microsyst Technol 24, 669–681 (2018). https://doi.org/10.1007/s00542-017-3318-8

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