Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles

Technical Paper

Abstract

This paper describes fabrication of a new hemocompatible, magnetic nanoparticles based on magnetite and naturally occurring chitosan, potentially applicable as biomaterials to nanobiomedicine. We fabricated carboxy-functionalized magnetite–chitosan (Fe3O4–CS–BTCDA) nanocomposite particles by a simple two-stage protocol. Magnetite–chitosan (Fe3O4–CS) nanocomposite particles were first prepared via in situ chemical coprecipitation reactions using Fe2+ and Fe3+ salts in an alkaline aqueous solution of CS. Fe3O4–CS nanocomposite particles were then reacted with butanetetracarboxylic dianhydride (BTCDA) to obtain the Fe3O4–CS–BTCDA nanocomposite particles dispersible under physiological conditions. The obtained nanoparticles are superparamagnetic. The hemolytic activity of the Fe3O4–CS–BTCDA nanocomposite particles is very low and essential for practical bio-related applications.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Chemistry and Chemical Engineering, Graduate School of Science and EngineeringYamagata UniversityYonezawaJapan

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