Abstract
The art of sensing the variables in biological systems has posed a lot of challenges in medical field. The power of identifying the exact reason for a disease is of great challenge for any practitioner. The conglomeration of engineering with medicine has always contributed significantly to know the unknown in a more precise way. Sensors are the integral part of today’s medical diagnosis. They act as the finding tool for the practitioner by providing the relevant data about the parameter of interest to decode the unknown facts and causes for the disease to occur. Biosensor has taken the diagnosing technique to a new level of understanding the internal causes for any type of malfunctioning inside the human body. In order to understand the biosensor this paper attempts to bridge the gap by reviewing previous efforts. Importance of biomarker and nano biosensors are also considered for understanding the biosensor next level of applications.
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References
Ahammad AJS, Lee J-J, Rahman MA (2009) Electrochemical sensors based on carbon nanotubes. Sensors 9:2289–2319. doi:10.3390/s90402289
Chandra S, Barola N, Bahadur D (2011) Impedimetric biosensor for early detection of cervical cancer. R S Chem 47:11258–11260
Chiu T-C, Huang C-C (2009) Aptamer-functionalized nano-biosensors. Sensors 9:10356–10388. doi:10.3390/s91210356
Dell’Atti D, Zavaglia M, Tombelli S, Bertacca G, Cavazzana AO, Bevilacqua G, Minunni M, Mascini M (2007) Development of combined DNA-based piezoelectric biosensors for the simultaneous detection and genotyping of high risk Human Papilloma Virus strains. Clin Chim Acta 383:140–146
Fracchiolla NS, Artuso S, Cortelezzi A (2013) Biosensors in clinical practice: focus on oncohematology. Sensors 13:6423–6447. doi:10.3390/s130506423
Gouvêa CMCP (2011) Biosensors for health applications. Universidade Federal de Alfenas, Brazil
Grieshaber D, MacKenzie R, Vörös J, Reimhult E (2008) Electrochemical biosensors—sensor principles and architectures. Sensors 8:1400–1458
Jie G, Zhang J, Jie G, Wang L (2014) A novel quantum dot nanocluster as versatile probe for electrochemiluminescence and electrochemical assays of DNA and cancer cells. Biosens Bioelectron 52:69–75
Lee I, Luo X, Huang J, Cui XT, Yun M (2012) Detection of cardiac biomarkers using single polyaniline nanowire-based conductometric biosensors. Biosensors 2:205–220. doi:10.3390/bios2020205
Liu J, Qin Y, Li D, Wang T, Liu Y, Wang J, Wang E (2013) Highly sensitive and selective detection of cancer cell with a label-free electrochemical cytosensor. Biosens Bioelectron 41(2013):436–441
Maehashi K, Matsumoto K (2009) Label-free electrical detection using carbon nanotube-based biosensors. Sensors 9:5368–5378. doi:10.3390/s90705368
Malik P, Katyal V, Malik V, Asatkar A, Inwati G, Mukherjee TK (2013) Nanobiosensors: concepts and variations. Article ID 327435. doi:10.1155/2013/327435
Ngoepe M, Choonara YE, Tyagi C, Tomar LK, du Toit LC, Kumar P, Ndesendo VMK, Pillay V (2013) Integration of biosensors and drug delivery technologies for early detection and chronic management of illness. Sensors 13:7680–7713. doi:10.3390/s130607680
Park YK, Bold B, Lee WK, Jeon MH, An KH, Jeong SY, Shim YK (2011) d-(+)-Galactose-conjugated single-walled carbon nanotubes as new chemical probes for electrochemical biosensors for the cancer marker galectin. Int J Mol Sci 12:2946–2957. doi:10.3390/ijms12052946
Putzbach W, Ronkainen NJ (2013) Immobilization techniques in the fabrication of nanomaterial based electrochemical biosensors: a review. Sensors 13:4811–4840. doi:10.3390/s130404811
Qi H, Peng Y, Gao Q, Zhang C (2009) Applications of nanomaterials in electrogenerated chemiluminescence biosensors. Sensors 9:674–695. doi:10.3390/s90100674
Riccò R, Meneghello A, Enrichi F (2011) Signal enhancement in DNA microarray using dye doped silica nanoparticles: application to Human Papilloma Virus (HPV) detection. Biosens Bioelectron 26:2761–2765
Sahasrabuddhe VV, Luhn P, Wentzensen N (2011) Human papillomavirus and cervical cancer: biomarkers for improved prevention efforts. Future Microbiol 6(9). doi:10.2217/fmb.11.87
Tainaka K, Sakaguchi R, Hayashi H, Nakano S, Liew FF, Morii T (2010) Design strategies of fluorescent biosensors based on biological macromolecular receptors. Sensors 10:1355–1376. doi:10.3390/s100201355
Wan Y, Deng W, Su Y, Zhua X, Peng C, Hu H, Peng H, Song S, Fan C (2011) Carbon nanotube-based ultrasensitive multiplexing electrochemical immunosensor for cancer biomarkers. Biosens Bioelectron 30:93–99
Wang J (2006) Electrochemical biosensors: towards point-of-care cancer diagnostics. Biosens Bioelectron 21:1887–1892
Wang Y, Chen M, Zhang L, Ding Y, Luo Y, Xu Q, Shi J, Cao L, Fu W (2009) Rapid detection of human papilloma virus using a novel leaky surface acoustic wave peptide nucleic acid biosensor. Biosens Bioelectron 24(12):3455–3460. doi:10.1016/j.bios.2009.04.034
Xu L, Yu H, Akhras MS, Han S-J, Osterfeld S, White RL, Pourmand N, Wang SX (2008) Giant magnetoresistive biochip for DNA detection and HPV genotyping. Biosens Bioelectron 24(1):99–103. doi:10.1016/j.bios.2008.03.030
Zhang Y, Yang D, Weng L, Wang L (2013) Early lung cancer diagnosis by biosensors. Int J Mol Sci 14:15479–15509. doi:10.3390/ijms140815479
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Kumar, D.R.S., Rao, P.V. A comprehensive assessment on nano biosensor to sense cancer cells. Microsyst Technol 23, 821–827 (2017). https://doi.org/10.1007/s00542-016-3173-z
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DOI: https://doi.org/10.1007/s00542-016-3173-z