Abstract
The potential use of silicon nanowires as parts of future devices has triggered an increased interest in silicon nanowire research. The usage of COMSOL Multiphysics can improve the sensitivity of Bioelectronics to extend their stability and utility. Biosensors based on silicon nanowires promise highly sensitive dynamic label-free electrical for detection of biomolecules organic. In this paper, we investigated the effect of surface charge of the functional bio-interface of a nanowire field effect biosensor on the conductance of the nanowire through finite element calculations. The biosensor under consideration consisted of a silicon nanowire with radius of 15 nm surrounded by a 3-nm oxide layer, and it is surrounded by a 4 nm thick functional bio-interface layer. This whole system is immerged in an electrolyte and each of the layers was treated as a continuum medium characterized by the corresponding dielectric constant. First, the distribution of the electrostatic has potential in the narrower due to the surface charge. Then, the conductance of the nanowire was computed though integrating the effect of the potential on the charge carriers within the narrower and it is computed using Poisson equation with Boltzmann statistics. Finite element calculations showed the nonlinear dependence of the nanowire conductance on the bio-interface surface charge. The conclusion of the paper is the electrical potential distribution was found by solving these approximated equations.
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References
Dhahi S, Hashim U, Ali ME (2012) Less than 10-nm gap silicon and polysilicon electrodes for sensing pH and yeast concentration. Curr Nanosci 8(6):925–929
Elibol OH, Morisette D, Akin D, Bashir R (2003) Integrated nanoscale silicon sensors using top-down fabrication. Appl Phys Lett 83(22):4613–4615
Ermakov IV, Van der Sande G, Danckaert J (2012) Semiconductor ring laser subject to delayed optical feedback: bifurcations and stability. Commun Nonlinear Sci Numer Simul 17:4767–4779
Falconia C, Mantinia G, D’Amico A, Wang ZL (2009) Studying piezoelectric nanowires and nanowalls for energy harvesting. Sens Actuator B 139:511–519
Gao Z, Agarwal A, Trigg AD, Singh N, Fang C, Tung C-H, Fan Y, Buddharaju KD, Kong J (2007) Silicon nanowire arrays for label-free detection of DNA. Anal Chem 79:3291–3297
Griffiths DJ (1989) Introduction to electrodynamics. Prentice-Hall International, ISBN No. 9780134816159
Hahm J, Leiber CM (2004) Direct ultrasensitive electrical detections of DNA and DNA sequence variations using nanowire nanosensors. Nano Letters 4(1):51–54
Hashim U, Shahrul Ariffin AB, Adam T (2012a) Fabrication of polysilicon nanowires using trimming technique. J Appl Sci Res 8(4):2175–2186
Hashim U, Diyana PNA, Adam T (2012b) Numerical simulation of microfluidic devices. J Appl Sci Res 8(4):2162–2174
Hashim U, Hamat NNH, Fatimah S, Adam T (2012c) Thermal diffusion: a simulation based study on shallow junction formation. Int J Nanoelectron Mater 5:77–86
Hashim U, Adam T, Al-Mufti MW, Ariffin SAB (2012d) Formation of polysilicon nanowires as transducer for biosensor using plasma trimming process. In: 2012 IEEE-EMBS conference on biomedical engineering and sciences, IECBES 2012, art. no. 6498013, pp 84–89
Kashif M, Usman Ali SM, Ali ME, Hashim U (2012) Effect of UV on impedance spectroscopy of Sn doped ZnO Nanorods. J Ovonic Res 8(3):91–96
Kim A, Ah CS, Yu HY, Yang JH, Baek IB, Ahn CG, Park CW, Jun MS, Lee S (2007) Ultrasensitive, label-free, and real-time immunodetection using silicon field-effect transistors. Appl Phys Lett. doi:10.1063/1.2779965
Martin Hedegård Sørensen (2009) Nanowire biosensor. M.Sc.Eng Thesis
Patolsky F, Zheng G, Lieber CM (2006) Nanowire-based biosensors. Anal Chem 78(13):4260–4269
Rahim Ruslinda A, Tajimaa S, Ishii Y, Ishiyama Y, Edgington R, Kawarada H (2010) Aptamer-based biosensor for sensitive PDGF detection using diamond transistor. Biosens Bioelectron 26:1599–1604
Scanlon S, Aggeli A (2008) Self-assembling peptide nanotubes. Nano Today 3(3–4):22–30
Sharma Rao B, Hashim U, Dhahi TS, Adam T (2012) DI water electrical characteristics monitoring using in house fabricated polysilicon nanoelectrode based transducer. Int J Enhanc Res Sci Technol Eng 1(1):1–6
Stern E, Klemic JF, Routenberg DA, Wyrembak PN, Turner-Evans DB, Hamilton AD, LaVan DA, Fahmy TM, Reed MA (2007) Label-free immunodetection with CMOS-compatible semiconducting nanowires. Nature 445:519–522
Thundat T, Ferrari M (2006) Nanotechnologies for bio-molecule detection and medical diagnostics. Curr Opin Chem Biol 10:11–19
Wesam Al-Mufti M, Hashim U, Adam T (2012) Current trend in simulation: review nanostructures using Comsol Multiphysics. J Appl Sci Res 8(12):5579–5582
Wesam Al-Mufti M, Hashim U, Adam T (2013) Simulation of nano lab on chip devices by using COMSOL Multiphysics. J Appl Sci Res 9(2):1062–1066
Wesam Al-Mufti M, Hashim U, Adam T (2014) The state of the arts: simulation of nanostructures using COMSOL Multiphysics, advanced materials research, vol 832. Trans Tech Publications, Switzerland, pp 206–211. doi:10.4028/www.scientific.net/AMR.832.206
Wang C-P, Liu C-W, Gau C (2011) Silicon nanowire temperature sensor and its characteristic. In: 2011 IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS), pp 630–633
Zheng GF, Patolsky F, Cui Y, Wang WU, Lieber CM (2005) Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nat Biotechnol 23:1294–1301
Acknowledgments
The authors wish to extend their sincere appreciation to Universiti Malaysia Perlis (UniMAP) for giving the opportunities to use the research facilities in the Bio-chip Fabrication and characterization Lab and Ministry of Science, Technology and Innovation (MOSTI) for providing us with grant to carry out this research. The appreciation also goes to all the team members in the Institute of Nanoelectronic Engineering especially in the Nano Biochip Research Group.
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Al-Mufti, A.W., Hashim, U., Rahman, M.M. et al. Nano–bio interface: the characterization of functional bio interface on silicon nanowire. Microsyst Technol 21, 1643–1649 (2015). https://doi.org/10.1007/s00542-014-2241-5
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DOI: https://doi.org/10.1007/s00542-014-2241-5