Advertisement

Microsystem Technologies

, Volume 18, Issue 6, pp 823–832 | Cite as

Analytical, numerical and experimental investigations of mixing fluids in microchannel

  • P. K. Sahu
  • A. Golia
  • A. K. Sen
Technical Paper

Abstract

This work presents theoretical analysis, numerical simulation, fabrication and test of a micromixer chip for mixing fluids in microchannel. A three-dimensional analytical model is developed using a different mathematical approach to study passive laminar mixing phenomena and predict concentration distribution in a microchannel. The analytical model is validated by comparing with experimental and simulation results. The process of mixing fluids in a microchannel is simulated by solving the continuity, momentum and mass diffusion equations. The simulation results are validated and then parametric studies are performed to investigate the effects of channel aspect ratio, Reynolds number and diffusion coefficient on the mixing performance. The micromixer chip is fabricated with patterned SU-8 photoresist as the microchannel layer on a PMMA substrate using a combination of photolithography and micro-milling. Experiments are performed with different mixing fluids and the results were compared with that obtained from the theoretical model and simulation results.

Keywords

High Aspect Ratio Microfluidic Chip Follow Boundary Condition Active Mixer PMMA Substrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors would like to acknowledge the Science and Engineering Research Council (SERC), Department of Science and Technology (DST), India for providing financial support for the project.

References

  1. Bao HH, Zhong J, Yi M (2001) A minute magneto hydro dynamic (MHD) mixer. Sensor Actuat B Chem 79:207–215CrossRefGoogle Scholar
  2. Berad DA (2001) Taylor dispersion of a solute in a microfluidic channel. J Appl Phys 89:4467–4469Google Scholar
  3. Culbertson CT, Jacobson SC, Ramsey JM (1998) Dispersion sources for compact geometries on microchips. Anal Chem 70:3781–3789CrossRefGoogle Scholar
  4. Ehrfeld W, Golbig K, Hessel V, we Lo H, Richter T (1999) Characterization of mixing in micromixers by a test reaction: single mixing units and mixing arrays. Ind Eng Chem Res 38:1075–1082CrossRefGoogle Scholar
  5. Erbacher C, Bessoth FG, Busch M, Verpoorte E, Manz A (1999) Towards integrated continuous-flow chemical reactors. Mikrochim Acta 131:19–24CrossRefGoogle Scholar
  6. Evans J, Liepmann D, Pisano AP (1997) Planar laminar mixer. In: Proceeding of the 10th IEEE international workshop on micro electro mechanical systems (MEMS’97), Nagoya, Japan, pp 96–101Google Scholar
  7. Gobby D, Angeli P, Gavriilidis A (2001) Mixing characteristics of T-type microfluidic mixers. J Micromech Microeng 11:126–132CrossRefGoogle Scholar
  8. Handique K, Burns MA (2001) Mathematical modeling of drop mixing in a slit-type microchannel. J Micromech Microeng 11:548–554CrossRefGoogle Scholar
  9. Holden MA, Kumar S, Castellana E, Beskok A, Cremer PS (2003) Generating fixed concentration arrays in a microfluidic device. Sensor Actuat B Chem 92:199–207CrossRefGoogle Scholar
  10. Ismagilov RF, Stroock AD, Kenis PJA, Whitesides G, Stone HA (2000) Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels. Appl Phys Lett 76:2376–2378CrossRefGoogle Scholar
  11. Kamholz AE, Yager P (2002) Molecular diffusive scaling laws in pressure-driven microfluidic channels: deviation from onedimensional Einstein approximations. Sensor Actuat B Chem 82:117–121Google Scholar
  12. Kamholz AE, Weigl BH, Finlayson BA, Yager P (1999) Quantitative analysis of molecular interaction in a microfluidic channel: the T-sensor. Anal Chem 71:5340–5347CrossRefGoogle Scholar
  13. Koch M, Chatelain D, Evans AGR, Brunnschweiler A (1998) Two simple micromixers based on silicon. J Micromech Microeng 8:123–126CrossRefGoogle Scholar
  14. Koch M, Witt H, Evans G, Brunnschweiler A (1999) Improved characterization technique for micromixers. J Micromech Microeng 9:156–158CrossRefGoogle Scholar
  15. Liu H, Lenigk R, Druyor-Sanchez RL, Yang J, Grodzinski P (2003) Hybridization enhancement using cavitation microstreaming. Anal Chem 75:1911–1917CrossRefGoogle Scholar
  16. Lu LH, Ryu K, Liu C (2002) A magnetic microstirrer and array for microfluidic mixing. J Microelectromech Syst 11:462–469CrossRefGoogle Scholar
  17. Miyake R, Lammerink TSJ, Elwenspoek M, Fluitman JHJ (1993) Micro mixer with fast diffusion. In: Proceedings of the 6th IEEE international workshop on micro electro mechanical systems (MEMS’93). Fort Lauderdale, Florida, pp 248–253Google Scholar
  18. Nguyen NT, Wu Z (2005) Micromixers—a review. J Micromech Microeng 15:R1–R16CrossRefGoogle Scholar
  19. Oddy MH, Santiago JG, Mikkelsen JC (2001) Electrokinetic instability micromixing. Anal Chem 73:5822–5832CrossRefGoogle Scholar
  20. Schwesinger N, Frank T, Wurmus H (1996) A modular microfluid system with an integrated micromixer. J Micromech Microeng 6:99–102CrossRefGoogle Scholar
  21. Tsai JH, Lin L (2002) Active microfluidic mixer and gas bubble filter driven by thermal bubble micropump. Sensor Actuat A Phys 97–98:665–671CrossRefGoogle Scholar
  22. Virk MS, Holdo AE (2008) Numerical analysis of fluid mixing in T-Type micro mixer. The Int J of Multiphysics 2(1):107–127CrossRefGoogle Scholar
  23. Yang Z, Goto H, Matsumoto M, Maeda R (2001) Ultrasonic micromixer for microfluidic systems. Sens Actuator A Phys 93:266–272CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Mechanical EngineeringIndian Institute of Technology GuwahatiGuwahatiIndia
  2. 2.Department of Mechanical EngineeringIndian Institute of Technology MadrasChennaiIndia

Personalised recommendations