Abstract
The effect of human atrial natriuretic peptide (hANP) on blood pressure (Bp) was evaluated in 11 patients who had elevated systoric Bp of over 150 mmHg during surgery. A bolus injection of 50μg or 100μg of hANP decreased Bp with an immediate response by 27.6±3.1 mmHg (P<0.001) or 40.7±4.2 mmHg (P<0.001), respectively, accompanying with tremendously increased urine output. Heart rate and\(Pa_{O_2 } \) were not altered. Thus, a intravenous bolus injection of hANP is an useful therapeutic tool for the treatment of acutely elevated Bp during anesthesia.
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Iwatsuki, N., Katoh, M., Yasuda, A. et al. Effects of intravenously administered human atrial natriuretic peptide on elevated blood pressure during surgery. J Anesth 3, 218–222 (1989). https://doi.org/10.1007/s0054090030218
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DOI: https://doi.org/10.1007/s0054090030218