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Effects of various catecholamines on high-energy phosphates of rat liver and brain during hemorrhagic shock measured by31p-NMR spectroscopy

  • Anesthesia
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Abstract

The effects of dopamine, epinephrine and norepinephrine on energy metabolism as well as intracellular pH in rat liver and brain during hemorrhagic shock were examined by in vivo31p-NMR spectroscopy. The hemorrhagic shock was induced by arterial bleeding to a mean arterial pressure (MAP) of 30–40 mmHg. Upon the induction of hemorrhagic shock, there was a dramatic fall in adenosine triphosphate (ATP) and a rise in inorganic phosphate (Pi) in the liver. The intracellular pH indicated severe acidosis. However, no change in these parameters was observed in the brain during hemorrhagic shock. After infusion of the above catechollamines following 10 min of hemorrhagic shock, MAP increased to 90–100% of its control value. Only dopamine improved hepatic energy metabolism, whereas brain evergy metabolism was not affected by any of them. This suggests that dopamine protects liver function during hemorrhagic shock without affecting brain energy metabolism.

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Authors and Affiliations

  1. Bioenergy Research Center, Tokushima Institute, Otsuka Pharmaceutical Co., Tokushima, Japan

    Takayuki Sogabe & Iwano Miura

  2. Department of Anesthesiology, Mie University, School of Medicine, Tsu, 514, Mie-ken, Japan

    Masahiro Okuda & Mannosuke Muneyuki

Authors
  1. Masahiro Okuda
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  2. Mannosuke Muneyuki
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  3. Takayuki Sogabe
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  4. Iwano Miura
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Okuda, M., Muneyuki, M., Sogabe, T. et al. Effects of various catecholamines on high-energy phosphates of rat liver and brain during hemorrhagic shock measured by31p-NMR spectroscopy. J Anesth 3, 200–209 (1989). https://doi.org/10.1007/s0054090030200

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  • DOI: https://doi.org/10.1007/s0054090030200

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