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The effect of hyperoxia on the lungs of rats deficient in essential fatty acids

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Abstract

Morphological alterations in the lungs of rats deficient in either or both of vitamin E and essential fatty acids were investigated after exposure to hyperoxia for 48 h. In rats deficient in both vitamin E and essential fatty acids, there was damage to type-2 alveolar cells observed as swollen mitochondria and bleb formation in the cytoplasm. None of these changes was found in rats deficient in only one of these substances. Hyperoxia in rats deficient in both substance also caused destruction of the capillary endothelial cells and edema in the interstitium. The lungs of rats deficient in only one of the substances showed some edema in the capillary endothelial cells, but not destruction, and less interstitial edema. These findings suggest that simultaneous deficiency in vitamin E and essential fatty acids facilitates lung damage in rats exposed to hyperoxia.

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Author notes

  1. Hidefumi Obara

    Present address: Department of Anesthesiology, Kobe University School of Medicine, Kusunokicho 7, Chuoku, 650, Kobe, Japan

Authors and Affiliations

  1. Department of Pediatrics, Kobe University School of Medicine, 650, Kobe, Japan

    Ryusuke Murakami, Tetsuya Momota, Akiyoshi Tanaka & Hajime Nakamura

  2. Department of Anesthesiology, Kobe University School of Medicine, Kusunokicho 7, Chuoku, 650, Kobe, Japan

    Katsuya Mikawa & Seizo Iwai

Authors
  1. Ryusuke Murakami
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  2. Hidefumi Obara
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  3. Tetsuya Momota
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  4. Akiyoshi Tanaka
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  5. Hajime Nakamura
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  6. Katsuya Mikawa
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  7. Seizo Iwai
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Murakami, R., Obara, H., Momota, T. et al. The effect of hyperoxia on the lungs of rats deficient in essential fatty acids. J Anesth 3, 149–154 (1989). https://doi.org/10.1007/s0054090030149

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  • DOI: https://doi.org/10.1007/s0054090030149

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