Advertisement

Journal of Anesthesia

, Volume 3, Issue 1, pp 74–79 | Cite as

Radioallergosorbent test (RAST) for specific IgE antibody to lidocaine, procaine and methylparaben

  • Masahiro Kokubu
  • Kazuaki Oda
  • Noboru Shinya
Original Articles

Abstract

Although anaphylactoid reactions to local anesthetics are well known, a radioallergosorbent test (RAST) to detect specific drug reagin (IgE) anti-body has not been developed. We established RAST for local anesthetics by using carboxylic acid derivatives of lidocaine, procaine and methylparaben. Serum samples were taken from 100 volunteers who were regarded to be nonallergic to the drugs used. Negative RAST values obtained from these volunteers were 1653 ± 254(SD) cpm (lidocaine), 2750 ± 264 cpm (procaine), and 2805 ± 336 cpm (methyl paraben).

Key words

RAST local anesthetics lidocaine procaine methylparaben 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Fregert S, Tegner E, Thelin I: Contact allergy to lidocaine. Contact Dermatitis 5:185–188, 1979CrossRefPubMedGoogle Scholar
  2. 2.
    Arora S, Aldrete JA: Investigation of possible allergy to local anesthetics drug. Anesthesiology review 13–16, 1976Google Scholar
  3. 3.
    Aldrete JA, Johnson DA: Allergy to local anesthetics. JAMA 207:356–357, 1969CrossRefPubMedGoogle Scholar
  4. 4.
    Timbury MC: Allergy to local anesthetics. Med J Australia 19:386, 1980Google Scholar
  5. 5.
    Falace DA, Hill JS: Allergy to lidocaine and mepivacaine: Report of a Case. Compend Contin Educ Denti 6:280–284, 1985Google Scholar
  6. 6.
    Wide L, Bennich H, Johansson SG: Diagnosis of allergy by an in-vitro test for allergen antibodies. Lancet 2:1105–1107, 1967CrossRefPubMedGoogle Scholar
  7. 7.
    Ceska M, Eriksson R, Varga JM: Radioimmunosorvent assay of allergens. J Allergy Clin Immunol 49:1–9, 1972CrossRefPubMedGoogle Scholar
  8. 8.
    Baldo BA, Fisher M McD: Detection of serum IgE antibodies that react with alcuronium and tubocuraine after lifethreatening reactions to muscle-relaxant drugs. Anesth Intensive Care 11:194–197, 1983Google Scholar
  9. 9.
    Yasuno H: A study on penicillin and cephalosporin allergy using radioallergosorbent test (Eng Abst). West Jap Derma 43:416–422, 1981Google Scholar
  10. 10.
    Aras K, Johansson SGO: The radioallergosorbent test in the in vitro diagnosis of multiple reaginic allergy. J Allergy Clin Immunol 48:134–143, 1971CrossRefGoogle Scholar
  11. 11.
    Bernard FE, Felix B, Sam MB, Seymour L: Steroid-Protein conjugates. J Biol Chern 128:713–727, 1957Google Scholar
  12. 12.
    Waldbott, GL: Allergic shock from local and general anesthetics, Anesth Analg 14:199–204, 1935CrossRefGoogle Scholar
  13. 13.
    Stenius B, Wide L: Reaginic antibody (IgE), skin and provocation tests to Dermatophagoides culinae and house dust in respiratory allergy. Lancet 2:455–457, 1969CrossRefPubMedGoogle Scholar

Copyright information

© Japanese Society of Anesthesiologists 1989

Authors and Affiliations

  • Masahiro Kokubu
    • 1
  • Kazuaki Oda
    • 2
  • Noboru Shinya
    • 1
  1. 1.Department of Anesthesiology, Faculty of DentistryHigashi Nippon Gakuen UniversityHokkaidoJapan
  2. 2.Faculty of Pharmacuetical sciencesHigashi Nippon Gakuen UniversityKanazawaJapan

Personalised recommendations