Journal of Anesthesia

, Volume 3, Issue 1, pp 74–79 | Cite as

Radioallergosorbent test (RAST) for specific IgE antibody to lidocaine, procaine and methylparaben

  • Masahiro Kokubu
  • Kazuaki Oda
  • Noboru Shinya
Original Articles


Although anaphylactoid reactions to local anesthetics are well known, a radioallergosorbent test (RAST) to detect specific drug reagin (IgE) anti-body has not been developed. We established RAST for local anesthetics by using carboxylic acid derivatives of lidocaine, procaine and methylparaben. Serum samples were taken from 100 volunteers who were regarded to be nonallergic to the drugs used. Negative RAST values obtained from these volunteers were 1653 ± 254(SD) cpm (lidocaine), 2750 ± 264 cpm (procaine), and 2805 ± 336 cpm (methyl paraben).

Key words

RAST local anesthetics lidocaine procaine methylparaben 


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Copyright information

© Japanese Society of Anesthesiologists 1989

Authors and Affiliations

  • Masahiro Kokubu
    • 1
  • Kazuaki Oda
    • 2
  • Noboru Shinya
    • 1
  1. 1.Department of Anesthesiology, Faculty of DentistryHigashi Nippon Gakuen UniversityHokkaidoJapan
  2. 2.Faculty of Pharmacuetical sciencesHigashi Nippon Gakuen UniversityKanazawaJapan

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