Abstract
The effects of halothane on AV nodal function were evaluated in dogs with verapamil, diltiazem, or nifedipine during atrial pacing using the technique of Hisbundle electrocardiography. Fifty-one mongrel dogs were divided into six groups. Anesthesia was induced with ketamine 100 mg im. and thiamylal 25 mg/kg iv. The animals were intubated and mechanically ventilated at normocapneic levels. Anesthesia was maintained with 50% nitrous-oxide in oxygen with pancuronium 2 mg im. Dogs in groups I, III, and V were anesthetized with 0.8% halothane and 50% nitrous-oxide in oxygen. We observed interactions between halothane and intravenous administration of either verapamil 0.1 mg/kg, diltiazem 0.15 mg/kg, or nifedipine 0.01 mg/kg respectively. Dogs in groups II, IV, and VI were administered either verapamil, diltiazem, or nifedipine iv without halothane. There were prolongations of sinus cycle length (SCL) (414±10 to 542±19 msec.), atrium-His (AH) interval (73±3 to 97±5 msec.), and functional refractory period (FRP) of the AV-node (227±5 to 260±5 msec.) in halothane anesthesia in groups I, III, and V. There were more prolongations of these variables after iv administration of verapamil (SCL; 617±35, AH; 118±7, FRP ofthe AV node; 311±4) and diltiazem (SCL; 554±19, AH; 118±12, FRP of the AV node; 283±12) but no prolongations after nifedipine (SCL; 533±19, AH; 99±8, FRP of the AV node; 272±9). Comparing effects of calcium entry blockers with and without halothane in groups I and II, III and IV, or V and VI, there were additive depressing effects of halothane with either verapamil or diltsazem on AV nodal function. And there is a difference between the effects of nifedipine on SCL with and without halothane.
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Yokota, S., Harada, K., Takigawa, C. et al. Effects of halothane and calcium entry blockers on atrioventricular conduction. J Anesth 2, 219–226 (1988). https://doi.org/10.1007/s0054080020219
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DOI: https://doi.org/10.1007/s0054080020219