Abstract
The effect of differential lung ventilation (DLV) on afferent vagal and efferent phrenic nerve activities was studied in urethane anesthetized cats. One endotracheal tube was inserted into the left bronchus to ventilate its side lung. Another tube was inserted until its tip reached about 1 cm above the carina to ventilate the right lung. Using two respirators, each lung was ventilated independently. Using hooked silver electrodes, the vagal and phrenic nerve activities were recorded.
The afferent vagal nerve was activated in concurrence with lung inflation at any ventilation rate. The right and left vagal nerves were activated by right and left lung ventilation, respectively. On the other hand, the right and left efferent phrenic nerves were synchronized, whether the ventilation was disused or ventilation was achieved by right or left one lung ventilation or even by asynchronous DLV.
The phrenic nerve activity was surpressed by one-lung, right or left, ventilation independently, so that the rhythm of the phrenic nerve was disturbed by asynchronous DLV. From these results, to reduce the stress of patients during asychronous DLV, it was considered that patients need heavier sedation than a usual mechanical ventilatory support.
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References
Gallagher TJ, Banner MJ, Smith RA: A simplified method of independent lung ventilation. Crit Care Med 8:396–399, 1980
Carlon GC, Ray C, Klein R, Goldiner PL, Miodownik S: Criteria for selective positive end-expiratory pressure and independent synchronized ventilation of each lung. Chest 74:501–507, 1978
Baehrendtz S, Hedenstierna G: Differential ventilation and selective positive endexpiratory pressure: Effects on patients with acute bilateral lung disease. Anesthesiology 61:511–517, 1984
Popovich Jr J, Sanders Jr OJ, Vij D, Polanski JJ, Conway WA: Differential lung ventilation with a modified ventilator. Crit Care Med 9:490–493, 1981
East TD, Pace NL, Westenskow DR: Synchronous versus asynchronous differential lung ventilation with PEEP after unilateral acid aspiration in the dog. Crit Care Med 11:441–444, 1983
Hillman KM, Barber JD: Asynchronous independent lung ventilation (AILV). Crit Care Med 8:390–395, 1980
Muneyuki M, Konishi K, Horiguchi R, Tsujimoto S, Saito M, Sakakura S, Konoshi A; Effects of alternating lung ventilation on cardiopulmonary function in dog. Anesthesiology 58:353–356, 1983
Jonzon A: Phrenic and vagal nerve activities during spontaneous respiration and positive-pressure ventilation. Acta Anaesthesiol Scand Suppl 64:29–35, 1977
Norsted T, Jonzon A, Rondio Z, Sedin G: Inhibition of phrenic nerve activity during positive-pressure ventilation at high and low frequencies. Acta Anaesthesiol Scand 30:521–528, 1986
Euler CV: On the central pattern generator for the basic breathing rhythmicity. J Appl Physiol Respirat Environ Exercise Physiol 55:1647–1659, 1983
Cohen MJ: Neurogenesis of respiratory rhythm in the mammal. Physiological Review 59:1105–1173, 1979
Lambertsen CJ: Neural control of respiration. Edited by Mountcastel. VB The C.V. Mosby Company, 1980, pp.1749-1773
Grundy EM, Chekrabarti MK, Whitwam JG: Efferent phrenic nerve activity during induced changes in arterial pressure. Br J Anaesth 58:1414–1421, 1986
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Kasaba, T., Kosaka, Y. Phrenic Nerve and vagal nerve activities during differential lung ventilation in cats. J Anesth 2, 170–175 (1988). https://doi.org/10.1007/s0054080020170
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DOI: https://doi.org/10.1007/s0054080020170