Abstract
In experiments on an isolated rat heart lung preparation, the effects of 100% oxygen, 50% nitrous oxide or air on myocardial metabolism during recovery from anoxic heart failure were evaluated with intramyocardial high energy phosphates, lactate and glycogen. A hundred percent nitrous oxide was administered until the cardiac outpt decreased from 30 to 20 ml/min, and then 50% nitrous oxide, air or 100% oxygen was administered. Fifty percent nitrous oxide reduced the cardiac output and caused heart failure again. The ATP level and energy charge in hearts with 50% nitrous oxide were significantly lower than those in the others. These data indicate that 50% nitrous oxide during recovery from anoxic heart failure had deleterious effects on myocardial function and metabolism.
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Kashimoto, S., Hinohara, Si. & Kumazawa, T. Fifty percent nitrous oxide depresses recovery from anoxic heart failure induced by 100% nitrous oxide. J Anesth 1, 119–124 (1987). https://doi.org/10.1007/s0054070010119
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DOI: https://doi.org/10.1007/s0054070010119