Skip to main content

Plasma histamine levels during induction of anesthesia with propofol in dogs

Abstract

We examined a property of emulsion formation of propofol (ICI 35868) to release histamine into circulating plasma in dogs. Plasma histamine was measured with radioimmunoassay before (baseline), and 1,5 and 10 min after the administration of 15 mg·kg−1 propofol. There were no significant differences between the plasma histamine levels at 1, 5 and 10 min after the administration of propofol and the baseline level. We conclude that the emulsion formation of propofol of 15 mg·kg− 1 does not release histamine during induction of anesthesia in dogs.

This is a preview of subscription content, access via your institution.

References

  1. Schatz M, Fung DL: Anaphylactic and anaphylactoid reactions due to anesthetic agents. Clin Rev Allergy 4:215–227, 1986

    CAS  PubMed  Google Scholar 

  2. Fisher MM: Direct histamine release in anaesthesia and surgery: unanswered questions. Theor Surg 3:145–147, 1988

    Google Scholar 

  3. Reilly CS, Nimmo WS: New intravenous anaesthetics and neuromuscular blocking drugs. A review of their properties and clinical use. Drugs 34:98–135, 1987

    Article  CAS  PubMed  Google Scholar 

  4. Langley MS, Heel RC: Propofol A review of its pharmacodymanics and pharmacokinetic properties and use as an intrvenous anaesthetic. Drugs 35:334–372, 1988

    Article  CAS  PubMed  Google Scholar 

  5. Kanto JH: Propofol, the newest induction agent of anesthesia. International J Clin Pharmacol Ther Toxicol 26:41–57, 1988

    CAS  Google Scholar 

  6. Briggs LP, Clarke RSJ, Watkins J: An adverse reaction to the administration of disoprofol (Diprivan). Anaesthesia 37:1099–1101, 1982

    Article  CAS  PubMed  Google Scholar 

  7. Watkins J; Testsin vivo andin vitro of hypersensitivity response, Guide to immediate anaesthetic reactions. Edited by Watkins J. London, Butterworths, 1988, pp. 101–115

    Google Scholar 

  8. McBride P, Bradley D, Kaliner M: Evaluation of a radioimmunoassay for histamine measurement in biologic fluids. Clin Immunol 82:638–646, 1988

    CAS  Google Scholar 

  9. Glen JB, Hunter SC: Pharmacology of an emulsion formation of ICI 35858. Br J Anaesth 56:617–626, 1984

    Article  CAS  PubMed  Google Scholar 

  10. Doenicke A, Lorenz W, Stanworth D, et al: Effects of propofol (‘Diprivan’) on histamine release, immunoglobin levels and activation of complement in healthy volunteers. Postgrad Med J 61 (Suppl. 3):15–20, 1985

    CAS  PubMed  Google Scholar 

  11. Dudziak R, Förster H, Hoffmann E, et al: Das Verhalten des Histaminspiegels während der Einleitung der Anaesthesie mit Propofol und Methohexital. Anaesthesist 36:412–419, 1987

    CAS  PubMed  Google Scholar 

  12. Lorenz W, Meyer R, Doenicke A, et al: On the species specifity of the histamine release from mast cell stores by cremophor-EL. Naunyn-Schmiedeberg’s Arch Parmacol 269:417–418, 1971

    Google Scholar 

  13. Laxenaire MC, Khamel L, Heravi Z, et al: Hist.aminolibération non specifique et propofol. Ann Fr Anesth Réanim 6:230–232, 1987

    CAS  PubMed  Google Scholar 

  14. Widmer S, Laxenaire MS, Manel J, et al: Étude du pouvoir hitaminoliberateurin vivo des hypnotiques (thiopental, methohexital, propofol) par dosages d’histamine plasmatique. Allerg Immunol 20:346–347, 1988

    CAS  Google Scholar 

  15. Withington DE: Basophil histamine release studies in the evaluation of a new anaesthetic agent. Agents Actions 23:337–338, 1988

    Article  CAS  PubMed  Google Scholar 

  16. Williamson J: Safe induction with propofol following thiopentone anaphylaxis. Anesth Inten Care 18:277–228, 1990

    CAS  Google Scholar 

  17. Laxenaire MC, Gueant JL, Bermejo E, et al: Anaphylactic shock due to propofol. Lancet 2:739–740,1988

    Article  CAS  PubMed  Google Scholar 

  18. Mouton C, Mata E, Gerrard P, et al: Premier cas de choc anaphylactique au propofol, agent anesthésique récent. Ann Med Nancy et de L’est 29:47, 1990

    Google Scholar 

  19. Nauquih M: Anaphylactoid reactions following propofol-atracurium sequence. Can J Anesth 36:358–366, 1989

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

About this article

Cite this article

Mitsuhata, H., Shimizu, R. Plasma histamine levels during induction of anesthesia with propofol in dogs. J Anesth 7, 206–209 (1993). https://doi.org/10.1007/s0054030070206

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s0054030070206

Key words

  • propofol
  • dog
  • histamine
  • intravenous anaesthetic