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Plasma histamine levels during induction of anesthesia with propofol in dogs

Journal of Anesthesia volume 7, pages 206–209 (1993)Cite this article

Abstract

We examined a property of emulsion formation of propofol (ICI 35868) to release histamine into circulating plasma in dogs. Plasma histamine was measured with radioimmunoassay before (baseline), and 1,5 and 10 min after the administration of 15 mg·kg−1 propofol. There were no significant differences between the plasma histamine levels at 1, 5 and 10 min after the administration of propofol and the baseline level. We conclude that the emulsion formation of propofol of 15 mg·kg− 1 does not release histamine during induction of anesthesia in dogs.

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Authors and Affiliations

  1. Department of Anesthesiology, Jichi Medical School, 3311-1, Yakushiji, Minamikawachi, Kawachi-Gun, Tochigi-ken, 329-04, Japan

    Hiromasa Mitsuhata & Reiju Shimizu

Authors
  1. Hiromasa Mitsuhata
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  2. Reiju Shimizu
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Cite this article

Mitsuhata, H., Shimizu, R. Plasma histamine levels during induction of anesthesia with propofol in dogs. J Anesth 7, 206–209 (1993). https://doi.org/10.1007/s0054030070206

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  • DOI: https://doi.org/10.1007/s0054030070206

Key words

  • propofol
  • dog
  • histamine
  • intravenous anaesthetic