Journal of Anesthesia

, Volume 6, Issue 4, pp 426–432 | Cite as

Serum fluoride concentration after sevoflurane anesthesia in ethanol treated rats: Special reference to cytochrome P-450 in the liver

  • Eiji Masaki
  • Tsutomu Kondou
  • Junichi Hirakawa
  • Masahiro Kawamura
  • Yoshikiyo Amaki
Original Articles


The relationship between serum concentration of inorganic fluoride (F) and cytochrome P-450 content after sevoflurane anesthesia was investigated in ethanol treated rats. Twenty male Wistar rats were randomly divided into 2 isocaloric diet groups of 10 rats each: one group receiving a standard diet and the other an ethanol diet. After 28 days on the diets the animals were administered 2.5% sevoflurane for 2 hr with 30% oxygen and 70% nitrous oxide. Cytochrome P-450 and cytochrome b-, were induced by the ethanol diet. In the ethanol diet group serum concentration of F was significantly higher than that of the standard diet group after sevoflurane anesthesia. These results suggest that cytochrome P-450 and b 5 , which were induced by ethanol, enhanced sevoflurane defluorination.

Key words

sevoflurane ethanol inorganic fluoride cytochrome P-450 cytochrome b5 


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Copyright information

© Japanese Society of Anesthesiologists 1992

Authors and Affiliations

  • Eiji Masaki
    • 3
  • Tsutomu Kondou
    • 3
  • Junichi Hirakawa
    • 1
  • Masahiro Kawamura
    • 2
  • Yoshikiyo Amaki
    • 3
  1. 1.Internal Medicine IJikei University School of MedicineTokyoJapan
  2. 2.Pharmacology IJikei University School of MedicineTokyoJapan
  3. 3.Department of Anesthesiology, E & R 3071Henry Ford HospitalDetroit

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