Serum fluoride concentration after sevoflurane anesthesia in ethanol treated rats: Special reference to cytochrome P-450 in the liver
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The relationship between serum concentration of inorganic fluoride (F−) and cytochrome P-450 content after sevoflurane anesthesia was investigated in ethanol treated rats. Twenty male Wistar rats were randomly divided into 2 isocaloric diet groups of 10 rats each: one group receiving a standard diet and the other an ethanol diet. After 28 days on the diets the animals were administered 2.5% sevoflurane for 2 hr with 30% oxygen and 70% nitrous oxide. Cytochrome P-450 and cytochrome b-, were induced by the ethanol diet. In the ethanol diet group serum concentration of F− was significantly higher than that of the standard diet group after sevoflurane anesthesia. These results suggest that cytochrome P-450 and b 5 , which were induced by ethanol, enhanced sevoflurane defluorination.
Key wordssevoflurane ethanol inorganic fluoride cytochrome P-450 cytochrome b5
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