Abstract
The effects of a novel benzodiazepine derivative, Ro 16–6028 on rat brain dopamine system were examined under stress and non-stress conditions. Thirty minutes restraint stress increased dopamine synthesis in two dopamine neuron regions, prefrontal cortex and nucleus accumbence. Ro 16–6028 inhibited potently dopamine synthesis in prefrontal cortex, nucleus accumbens and striatum in dose dependent manner under non-stress condition. Furthermore, Ro 16–6028 reverses the stress-induced augmentation of the synthesis in prefrontal cortex. These findings indicate that Ro 16–6028 has an anxiolytic profile and that central dopamine system plays an important role in stress reaction.
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Harada, K., Noguchi, K. & Wakusawa, R. Effects of immobilization stress and of a benzodiazepine derivative on rat central dopamine system. J Anesth 6, 167–171 (1992). https://doi.org/10.1007/s0054020060167
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DOI: https://doi.org/10.1007/s0054020060167