Abstract
The efficacy of a low dose of PGE1-use on the postoperative liver damage was evaluated. PGE1 was infused in with the mean rate of 0.026 μg·kg−1·min−1 during surgical procedure to 93 patients under GO-enflurane anesthesia (the PG). Serum GOT, GPT and total bilirubin (TBIL) values measured before, at the end of (End) and 3 days (3d) after the operation were compared to those obtained from 43 patients without PGE1 administration (the control).
This dose of PGE1 did not change blood pressure and heart rate, but slightly decreased\(Pa_{O_2 } \). In patients with preoperative normal values of GOT, GPT and TBIL, increases in GOT, GPT and TBIL observed at End in the PG were significantly lower than those in the control (31.9 vs 72.2 IU, 25.9 vs 61.9 IU, 0.68 vs 0.83 mg·dl−1, respectively). GOT, GPT and TBIL at 3d significantly increased in both groups, and these levels were identical between the two groups. In patients with preoperative abnormal values, only GOT at End increased in both groups, while no significant difference between the PG and the control group was noted. GOT at 3d and GPT at End and 3d did not significantly changed in either group. These results suggest that the low dose of PGE1 administered during an operation prevents the development of postoperative liver damage, but does not treat the damaged hepatic cells.
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Iwatsuki, N., Yasuda, A., Tokutomi, S. et al. Preventative effect of PGE1 for postoperative liver damage. J Anesth 6, 131–137 (1992). https://doi.org/10.1007/s0054020060131
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DOI: https://doi.org/10.1007/s0054020060131