Abstract
Forty three children ranged from 1 yr. to 6 yr. were randomly assigned to non-atropinized group (n=20; A(−) and atropinized group (0.015 mg·kg-1 i.m., n=23; A(+)). Control hemodynamics were measured under 0.5% halothane and 67% nitrous oxide and 33% oxygen for three minutes, and then halothane was increased to 2.5% and maintained for 15 min. In the A(−) group, stroke volume (SV) decreased to 64%, heart rate (HR) increased from 100/min to 111/min, and blood pressure (BP) decreased from 67 mmHg to 62 mmHg. Skin blood flow (SBF) concomitantly measured by a laser doppler flowmeter decreased to 48% and total peripheral resistance (TPR) increased to 128%. In the A(+) group, HR increased from ll7/min to 132/min (P<0.05, vs. A(−) group), BP decreased from 67 mmHg to 66 mmHg. SV decreased to 71% (P<0.05, vs. A(−) group). Changes in SBF and TPR were 68% and 128% respectively. End-expired halothane concentration in the A(+) group increased slower than in the A(−) group but not significantly. The results indicate increased sympathetic tone would work as a compensating mechanism for decreased SV and CO. Atropine premedication attenuated cardiovascular depression by maintaing HR and possibly by delaying induction speed of anesthesia. In conclusion, halotane-nitrous oxide anesthesia decreased SV without a marked decrease in heart rate and blood pressure in children. This decrease in SV and BP was attenuated by atropine premedication.
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Kawana, S., Namiki, A., Morita, Y. et al. Hemodynamic responses during induction of anesthesia with halothane-nitrous oxide in children with or without atropine premedication. J Anesth 6, 63–68 (1992). https://doi.org/10.1007/s0054020060063
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DOI: https://doi.org/10.1007/s0054020060063