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Protective effects of prostaglandin I2 analogues on CPK release in rat’s heart-lung preparation

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Abstract

The effects of prostaglandin I2 analogues (PGI2-a: op-41483 and op-2507) on oxygen toxicity during hyperoxic perfusion were evaluated in an experiment on isolated rat heart lung preparation, with the release of creatine phosphokinase (CPK) in the perfusate blood. There were no significant differences in heart rate and right atrial pressure between PGI2-a treated and untreated hearts. The CPK release from the heart with oxygen was significantly higher than that of the air (P<0.001). However, the CPK release from the PGI2-a treated hearts was significantly less than that from the untreated hearts (P<0.05). These results indicate that PGI2-a may prevent cell damage which was induced by hyperoxia.

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Author notes

  1. Satoshi Kashimoto

    Present address: Department of Anesthesia, Kohfu City Hospital, 14-6, Saiwai-cho, 400, Kohfu-city, Yamanashi, Japan

Authors and Affiliations

  1. Department of Anesthesiology, Yamanashi Medical College, Yamanashi, Japan

    Takeshi Oguchi, Masaki Kume & Teruo Kumazawa

  2. Department of Anesthesia, Kohfu City Hospital, 14-6, Saiwai-cho, 400, Kohfu-city, Yamanashi, Japan

    Toshihiro Nakamura

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  1. Satoshi Kashimoto
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  2. Toshihiro Nakamura
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  3. Takeshi Oguchi
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  4. Masaki Kume
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  5. Teruo Kumazawa
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Kashimoto, S., Nakamura, T., Oguchi, T. et al. Protective effects of prostaglandin I2 analogues on CPK release in rat’s heart-lung preparation. J Anesth 5, 359–362 (1991). https://doi.org/10.1007/s0054010050359

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  • DOI: https://doi.org/10.1007/s0054010050359

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