Abstract
The effects of pancuronium and vecuronium, each in doses of 0.05 and 0.08 mg·kg−1, on the baroreflex control of the heart rate were studied in 40 adult patients of either sex (21 men and 19 women) during stable nitrous oxide-oxygen-fentanyl anesthesia. The blood pressure was elevated by intravenous infusion of phenylephrine (4 μgg·kg−1·min−1) for the pressor test, and lowered by a bolus injection of nitroglycerin (0.3–0.5 mg) for the depressor test. Baroreflex sensitivity was judged from the slope of the regression of the systolic blood pressure on the succeeding R-R intervals on the ECG. There was no significant difference between the baseline blood pressure at which both tests were carried out. Nitrous oxide-oxygen-fentanyl anesthesia alone suppressed the baroreflex sensitivity to a level which was at the lower limit of the physiological and non-anesthetized state. The 0.08 mg·kg−1 dose of pancuronium significantly suppressed the reflex sensitivity in both the pressor and depressor tests. However, the 0.05 mg·kg−1 dose of pancuronium and both doses of vecuronium did not cause any significant change in the test results.
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Tsuchida, H., Seki, S., Nakae, Y. et al. Difference in the effect of pancuronium and vecuronium on baroreflex control of heart rate in humans. J Anesth 5, 255–259 (1991). https://doi.org/10.1007/s0054010050255
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DOI: https://doi.org/10.1007/s0054010050255