Abstract
This study was undertaken to determine the effect of concentration of pHadjusted local anesthetics on the onset time of anesthesia. p ]Lidocaine (0.9% and 1.8%) and bupivacaine (0.25% and 0.5%) were used. In the 0.9 percent lidocaine and 0.25 percent bupivacaine groups, the onset time of analgesia was shortened by about 100 and 200 seconds, when pH was adjusted to 7.4 and 7.0, respectively (P<0.05 andP<0.01). In the 1.8 percent lidocaine and 0.5 percent bupivacaine groups, however, pH adjustment exerted no significant effect on the onset time.
Alkalinization of low-concentration local anesthetics shortened the onset time, whereas that of high-concentration did not shorten.
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References
Hilgier M: Alkalinization of bupivacaine for brachial plexus block. Reg Anaesth 10:59–61, 1985
DiFazio CA, Carron H, Grosslight KR, Moscicki JC, Bolding WR, Johns RA: Comparison of pH-adjusted lidocaine solutions for epidural anesthesia. Anesth Analg 65:760–764, 1986
McMorland GH, Douglas MJ, Jeffery WK, Ross PLE, Axelson JE, Kim JHK, Gambling DR, Robertson K: Effect of pHadjustment of bupivacaine on onset and duration of epidural analgesia in parturients. Can Anaesth Soc J 33:537–541, 1986
McMorland GH, Douglas MJ, Axelson JE, Kim JHK, Blair I, Ross PLE, Gambling DR, Swenerton JE: The effect of pH adjustment of bupivacaine on onset and duration of epidural anaesthesia for caesarean section. Can Anaesth Soc J 35:457–461, 1988
Bavoux E, Benhamou D, Clavier N, Perrachon N, Labaille T: Onset and duration of epidural analgesia with pH-adjusted bupivacaine: Is the change in pH the difference? Anesthesiology 69:(3A)A393, 1988
Galindo A: pH-adjusted local anesthetics: clinical experience. Reg Anaesth 8:35–36, 1983
Bedder MD, Kozody R, Craig DB: Comparison of bupivacaine and alkalinized bupivacaine in brachial plexus anesthesia. Anesth Analg 67:48–52, 1988
Glosten B, Dailey PA, Preston PG, Shnider SM, Ross BK, Rosen MA, Hughes SC: pH-adjusted 2-Chloroprocaine for epidural anesthesia in patients undergoing postpartum tubal ligation. Anesthesiology 68:948–950, 1988
Savarese JJ, Covino BG: 29. Basic and clinical pharmacology of local anesthetic drugs. In: Miller RD, ed. Anesthesia. 2nd ed New York: Churchill Livingstone, 1986, pp. 993–994
De Jong RH: Local Anesthetics. Springfield Illinois USA: Charles C Thomas, 1977, pp. 69
Cousins MJ, Bridenbaugh PO: Neural Blockade in Clinical Anesthesia and Management of pain. Philadelphia: J.B. Lippincott, 1980, pp. 50
Sato S, Naito H: The correlation between the onset time of local anesthetics and the anesthetic base concentration. Masui (Jpn J Anesthesiol) 31:920–926, 1982
Bromage PR: Epidural Analgesia. Philadelphia, London, Toronto: W.B. Saunders. 1978, pp. 80
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Fukuda, T., Sato, S. & Naito, H. Concentration- and pH-dependent effects of local anesthetics on onset of epidural anesthesia. J Anesth 4, 327–330 (1990). https://doi.org/10.1007/s0054000040327
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DOI: https://doi.org/10.1007/s0054000040327