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Differences in circulating blood volume changes during emergence from general anesthesia in transcatheter aortic valve implantation and MitraClip implantation

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Abstract

Purpose

We aimed to compare changes in the circulating blood volume (CBV) during emergence from general anesthesia in patients undergoing transcatheter aortic valve implantation (TAVI) and MitraClip implantation.

Method

We included 97 patients who underwent TAVI or MitraClip implantation. The primary outcome was the rate of change in the estimated CBV associated with emergence from general anesthesia. The secondary outcomes were hemoglobin and hematocrit values before and after emergence from anesthesia for each procedure. Additionally, the independent factors associated with changes in the estimated CBV were assessed using multiple regression analysis.

Results

In the TAVI group, the hemoglobin concentration increased from 9.6 g/dL before emergence from anesthesia to 10.8 g/dL after emergence (P < 0.001; mean difference, 1.2 g/dL, 95% confidence interval [CI] 1.1–1.3 g/dL). Conversely, no statistically significant change was observed in the hemoglobin concentration before and after emergence from anesthesia in the MitraClip group. The mean rate of change in the estimated CBV was − 15.4% (standard deviation [SD] 6.4%) in the TAVI group and − 2.4% (SD, 4.7%) in the MitraClip group, indicating a significant decrease in the estimated CBV in the former than in the latter (P < 0.001; mean difference, 13.0%; 95% CI 9.9–16.1%).

Conclusion

Emergence from general anesthesia increased the hemoglobin concentration and decreased the estimated CBV in patients undergoing TAVI but did not elicit significant changes in patients undergoing MitraClip implantation. These results may provide a rationale for minimizing blood transfusions during general anesthesia in patients undergoing these procedures.

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Data availability

Data will be shared in deidentified form upon reasonable request.

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Acknowledgements

We would like to thank Editage (www.editage.jp) for English language editing.

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Authors and Affiliations

  1. Department of Anesthesiology, Sapporo Medical University School of Medicine, 291, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, Japan

    Makishi Maeda, Yusuke Yoshikawa, Sho Ohno, Tomohiro Chaki & Michiaki Yamakage

Authors
  1. Makishi Maeda
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  2. Yusuke Yoshikawa
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  3. Sho Ohno
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  4. Tomohiro Chaki
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  5. Michiaki Yamakage
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Contributions

Makishi Maeda: Conceptualization, Methodology, Investigation, Data curation, Writing—Original Draft, and Visualization; Yusuke Yoshikawa: Conceptualization, Methodology, and Writing—Review and Editing; Sho Ohno: Conceptualization, Methodology, and Writing—Review and Editing; Tomohiro Chaki: Conceptualization, Methodology, Formal analysis, and Writing—Review and Editing; Michiaki Yamakage: Conceptualization, Writing—Review and Editing, and Supervision.

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Correspondence to Makishi Maeda.

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Maeda, M., Yoshikawa, Y., Ohno, S. et al. Differences in circulating blood volume changes during emergence from general anesthesia in transcatheter aortic valve implantation and MitraClip implantation. J Anesth (2024). https://doi.org/10.1007/s00540-024-03345-1

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  • DOI: https://doi.org/10.1007/s00540-024-03345-1

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