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Stroke volume variation and dynamic arterial elastance predict fluid responsiveness even in thoracoscopic esophagectomy: a prospective observational study



It remains unknown whether stroke volume variation (SVV), pulse pressure variation (PPV), and dynamic arterial elastance (Eadyn) are suitable for monitoring fluid management during thoracoscopic esophagectomy (TE) in the prone position with one-lung ventilation and artificial pneumothorax. Our study aimed to evaluate the accuracy of SVV, PVV, and Eadyn in predicting the fluid responsiveness in these patients.


We recruited 24 patients who had undergone TE. Patients with a mean arterial blood pressure ≤ 65 mmHg received a 200-ml bolus of 6% hydroxyethyl starch over 10 min. Fluid responders showed the stroke volume index ≥ 15% 5 min after the fluid bolus. Receiver operating characteristic (ROC) curves were generated and area under the ROC curve (AUROC) was calculated.


We obtained 61 fluid bolus data points, of which 20 were responders and 41 were non-responders. The median SVV before the fluid bolus in responders was significantly higher than that in non-responders (18% [interquartile range (IQR) 13–21] vs. 12% [IQR 8–15], P = 0.001). Eadyn was significantly lower in responders than in non-responders (0.55 [IQR 0.45–0.78] vs. 0.91 [IQR 0.67–1.00], P < 0.001). There was no difference in the PPV between the groups. The AUROC was 0.76 for SVV (95% confidence interval [CI] 0.62–0.89, P = 0.001), 0.56 for PPV (95% CI 0.41–0.71, P = 0.44), and 0.82 for Eadyn (95% CI 0.69–0.95, P < 0.001).


SVV and Eadyn are reliable parameters for predicting fluid responsiveness in patients undergoing TE.

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Data availability

The data that support the findings of this study are not openly available due to reasons of sensitivity and are available from the corresponding author upon reasonable request.


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The authors wish to acknowledge the members of the Data Science Division, Center for Innovative Clinical Medicine, Okayama University Hospital for their help with data entry in this study.

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Authors and Affiliations



All authors contributed to the study’s conception and design. Material preparation, data analysis were performed by YH and SS. The first draft of the manuscript was written by YH and SS and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Yukiko Hikasa.

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Conflict of interest

Yukiko Hikasa received research funding from Edwards Lifesciences for travelling to attend the conference. Satoshi Suzuki, Shunsuke Tanabe, Kazuhiro Noma, Yasuhiro Shirakawa, and Toshiyoshi Fujiwara have no conflict of interest. Hiroshi Morimatsu received a research funding from Edwards Lifesciences.

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Hikasa, Y., Suzuki, S., Tanabe, S. et al. Stroke volume variation and dynamic arterial elastance predict fluid responsiveness even in thoracoscopic esophagectomy: a prospective observational study. J Anesth 37, 930–937 (2023).

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