Skip to main content

Advertisement

SpringerLink
Log in

Correlation between pain catastrophizing in acute herpes zoster and postherpetic neuralgia: a retrospective analysis

  • Original Article
  • Published:
Journal of Anesthesia Aims and scope Submit manuscript

Abstract

Purpose

The objective of this study was to examine the association between pain catastrophizing in acute phase herpes zoster and the development of postherpetic neuralgia.

Methods

The medical records of all patients diagnosed with herpes zoster between February 2016 and December 2021 were retrieved. Inclusion criteria were patients aged > 50 years who visited our pain center within 60 days after rash onset and reported a pain intensity of ≥ 3 in a numerical rating scale. Patients with a score of 30 or more in the pain catastrophizing scale at baseline were assigned to the catastrophizer group, and those with a score < 30 were assigned to the non-catastrophizer group. We defined patients with “postherpetic neuralgia” and “severe postherpetic neuralgia” as those with a numerical rating scale score of 3 or more and 7 or more at 3 months after baseline, respectively.

Results

Data of 189 patients were available for complete analysis. Age, baseline numerical rating scale, and prevalence of anxiety and depression were significantly higher in the catastrophizer than those in the non-catastrophizer group. Incidence of postherpetic neuralgia did not differ significantly between the groups (p = 0.26). Multiple logistic regression analysis showed that age, severe pain at baseline, and immunosuppressive state were the factors which were independently associated with developing postherpetic neuralgia. Severe pain at baseline was the only factor related to developing severe postherpetic neuralgia.

Conclusion

Pain catastrophizing in the acute phase of herpes zoster may not be related to the development of postherpetic neuralgia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Data availability statement

The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.

References

  1. Birch S, Stilling M, Mechlenburg I, Hansen TB. The association between pain catastrophizing, physical function and pain in a cohort of patients undergoing knee arthroplasty. BMC Musculoskelet Disord. 2019;20:421. https://doi.org/10.1186/s12891-019-2787-6.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Moloney NA, Pocovi NC, Dylke ES, Graham PL, De Groef A. Psychological factors are associated with pain at all time frames after breast cancer surgery: a systematic review with meta-analyses. Pain Med. 2021;22:915–47. https://doi.org/10.1093/pm/pnaa363.

    Article  PubMed  Google Scholar 

  3. Sheikhzadeh A, Wertli MM, Weiner SS, Rasmussen-Barr E, Weiser S. Do psychological factors affect outcomes in musculoskeletal shoulder disorders? A systematic review. BMC Musculoskelet Disord. 2021;22:560. https://doi.org/10.1186/s12891-021-04359-6.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Giordano NA, Kane A, Jannace KC, Rojas W, Lindl MJ, Lujan E, Gelfand H, Kent ML, Highland KB. Discrete and dynamic postoperative pain catastrophizing trajectories across 6 months: a prospective observational study. Arch Phys Med Rehabil. 2020;101:1754–62. https://doi.org/10.1016/j.apmr.2020.04.023.

    Article  PubMed  Google Scholar 

  5. Kawai K, Gebremeskel BG, Acosta CJ. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open. 2014;4:e004833. https://doi.org/10.1136/bmjopen-2014-004833.

  6. Johnson RW, Alvarez-Pasquin MJ, Bijl M, Franco E, Gaillat J, Clara JG, Labetoulle M, Michel JP, Naldi L, Sanmarti LS, Weinke T. Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective. Ther Adv Vaccines. 2015;3:109–20. https://doi.org/10.1177/2051013615599151.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Bricout H, Perinetti E, Machettini P, Ragni P, Zotti CM, Gabutti G, Volpi A, Franco E. Burden of herpes zoster-associated chronic pain in Italian patients aged 50 years and over (2009–2010): a GP-based prospective cohort study. BMC infect Dis. 2014;14:637. https://doi.org/10.1186/s12879-014-0637-6.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Curran D, Schmidt-Ott R, Schutter U, Simon J, Anastassopoulou A, Matthews S. Impact of herpes zoster and postherpetic neuralgia on the quality of life of Germans aged 50 or above. BMC Infect Dis. 2018;18:496. https://doi.org/10.1186/s12879-018-3395-z.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Schmidt-Ott R, Schutter U, Simon J, Nautrup BP, von Krempelhuber A, Gopala K, Anastassopoulou A, Guignard A, Curran D, Matthews S, Espié E. Incidence and costs of herpes zoster and postherpetic neuralgia in German adults aged ≥ 50 years: a prospective study. J Infect. 2018;76:475–82. https://doi.org/10.1016/j.jinf.2018.02.001.

    Article  PubMed  Google Scholar 

  10. Zhou H, Wang Z, Jin H, Chen X, Lei L. A systematic review and meta-analysis of independent risk factors for postherpetic neuralgia. Ann Palliat Med. 2021;10:12181–9. https://doi.org/10.21037/apm-21-3028.

    Article  PubMed  Google Scholar 

  11. Xing XF, Zhou ZF, Zhang FJ, Yan M. The effect of early use of supplemental therapy on preventing postherpetic neuralgia: a systematic review and meta-analysis. Pain Phys. 2017;20:471–86.

    Google Scholar 

  12. Lin CS, Lin YC, Lao HC, Chen CC. Interventional treatments for postherpetic neuralgia: a systematic review. Pain Phys. 2019;22:209–28.

    Article  Google Scholar 

  13. Kim J, Kim MK, Choi GJ, Shin HY, Kim BG, Kang H. Pharmacological and non-pharmacological strategies for preventing postherpetic neuralgia: a systematic review and network meta-analysis. Korean J Pain. 2021;34:509–33. https://doi.org/10.3344/kjp.2021.34.4.509.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Coplan PM, Schmader K, Nikas A, Chan IS, Choo P, Levin MJ, Johnson G, Bauer M, Williams HM, Kaplan KM, Guess HA, Oxman MN. Development of a measure of the burden of pain due to herpes zoster and postherpetic neuralgia for prevention trials: adaptation of the brief pain inventory. J Pain. 2004;5:344–56. https://doi.org/10.1016/j.jpain.2004.06.001.

    Article  PubMed  Google Scholar 

  15. Sullivan MJL, Bishop SR, Pivik J. The pain catastrophizing scale: development and validation. Psychol Assess. 1995;7:524–32. https://doi.org/10.1037/1040-3590.7.4.524.

    Article  Google Scholar 

  16. Ikemoto T, Hayashi K, Shiro Y, Arai YC, Marcuzzi A, Costa D, Wrigley P. A systematic review of cross-cultural validation of the pain catastrophizing scale. Eur J Pain. 2020;24:1228–41. https://doi.org/10.1002/ejp.1587.

    Article  PubMed  Google Scholar 

  17. Dong DS, Yu X, Wan CF, Liu Y, Zhao L, Xi Q, Cui WY, Wang QS, Song T. Efficacy of short-term spinal cord stimulation in acute/subacute zoster-rerated pain: a retrospective study. Pain Phys. 2017;20:E633–45.

    Google Scholar 

  18. Liu W, Liu J, Ma L, Chen J. Effect of mindfulness yoga on anxiety and depression in early breast cancer patients received adjuvant chemo therapy: a randomized clinical trial. J Cancer Res Clin Oncol. 2022;148:2549–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Herdman M, Gudex C, Lloyd A, Janssen M, Kind P, Parkin D, Bonsel G, Badia X. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res. 2011;20:1727–36. https://doi.org/10.1007/s11136-011-9903-x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Alentado VJ, Caldwell S, Gould HP, Steinmetz MP, Benzel EC, Mroz TE. Independent predictors of a clinically significant improvement after lumbar fusion surgery. Spine J. 2017;17:236–43. https://doi.org/10.1016/j.spinee.2016.09.011.

    Article  Google Scholar 

  21. Bouhassia D, Chassany O, Gaillat J, Hanslik T, Launay O, Mann C, Rabaud C, Rogeau O, Strady C. Patient perspective on herpes zoster and its complications: an observational prospective study in patients aged over 50 years in general practice. Pain. 2012;153:342–9. https://doi.org/10.1016/j.pain.2011.10.026.

    Article  Google Scholar 

  22. Johnson RW, Alvares-Pasquin MJ, Bijl M, Franco E, Gaillat J, Clara JG, Labetoulle M, Michel JP, Naldi L, Sanmarti LS, Weinke T. Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective. Ther Adv Vaccines. 2015;3:109–20. https://doi.org/10.1177/2051013615599151.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Fujiwara A, Ida M, Watanabe K, Kawanishi H, Kimoto K, Yoshimura K, Shinohara K, Kawaguchi M. Prevalence and associated factors of disability in patients with chronic pain: an observational study. Medicine (Baltimore). 2021;100:e27482. https://doi.org/10.1097/MD.0000000000027482.

  24. Takao Y, Miyazaki Y, Okada M, Onishi F, Yano S, Gomi Y, Ishikawa T, Okuno Y, Mori Y, Asada H, Yamanishi K, Iso H. Incidence of herpes zoster and postherpetic neuralgia in Japanese adults aged 50 years older from community-based prospective study: the SHEZ study. J Epidemiol. 2015;25:617–25. https://doi.org/10.2188/jea.JE20140210.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Saguil A, Kane S, Mercado M, Lauters R. Herpes zoster and postherpetic neuralgia: prevention and management. Am Fam Phys. 2017;96:656–63.

    Google Scholar 

  26. Shiraki K, Toyama N, Tanaka K, Ito A, Yamamoto J, Members of the Miyazaki Dermatologist Society. Effect of universal varicella vaccination and behavioral changes against coronavirus disease 2019 pandemic on the incidence of herpes zoster. J Dermatol Sci. 2021;104:185–92. https://doi.org/10.1016/j.jdermsci.2021.10.007.

  27. Imafuku S, Nakayama K, Higa K, Furue M, Takahara M, Katayama I, Tani M. One-year follow-up of zoster-associated pain in 764 immunocompetent patients with acute herpes zoster treated with famciclovir (FAMILIAR study). J Eur Acad Dermatol Venereol. 2014;28:1716–22. https://doi.org/10.1111/jdv.12379.

    Article  CAS  PubMed  Google Scholar 

  28. Burns LC, Ritvo SE, Ferguson MK, Clarke H, Seltzer Z, Katz J. Pain catastrophizing as a risk factor for chronic pain after total knee arthroplasty: a systematic review. J Pain Res. 2015;8:21–32. https://doi.org/10.2147/JPR.S64730.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Habib AS, Kertai MD, Cooter M, Greenup RA, Hwang S. Risk factors for severe acute pain and persistent pain after surgery for breast cancer: a prospective observational study. Reg Anesth Pain Med. 2019;44:192–9. https://doi.org/10.1136/rapm-2018-000040.

    Article  PubMed  Google Scholar 

  30. Jochimsen KN, Pelton MR, Mattacola CG, Huston LJ, Reinke EK, Spindler KP, Lattermann C, Jacobs CA. Relationship between pain catastrophizing and 6-month outcomes following anterior cruciate ligament reconstruction. J Sport Rehabil. 2019;29:808–12. https://doi.org/10.1123/jsr.2018-0431.

    Article  PubMed  Google Scholar 

  31. Rogers AH, Farris SG. A meta-analysis of the associations of elements of the fear-avoidance model of chronic pain with negative affect, depression, anxiety, pain-related disability and pain intensity. Eur J Pain. 2022;26:1611–35. https://doi.org/10.1002/ejp.1994.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Racine M, Moulin DE, Nielson WR, Morley-Forster PK, Lynch M, Clark AJ, Stitt L, Gordon A, Nathan H, Smyth C, Ware MA, Jensen MP. The reciprocal association between catastrophizing and pain outcomes in patients being treated for neuropathic pain: a cross-lagged panel analysis study. Pain. 2016;157:1946–53. https://doi.org/10.1097/j.pain.0000000000000594.

    Article  PubMed  Google Scholar 

  33. Poulsen DM, Sorensen JCH, Blichfeldt-Eckhardt MR, Gulisano HA, Knudsen ALH, Nikolajsen L, Meier K. Pain catastrophizing does not predict spinal cord stimulation outcomes: a cohort study of 259 patients with long-term follow-up. Neuromodulation. 2021;24:76–85. https://doi.org/10.1111/ner.13213.

    Article  PubMed  Google Scholar 

  34. Xue S, Yang WJ, Cao ZX, Sun T. Comparing the efficacy and safety of short-term spinal cord stimulation and pulsed radiofrequency for zoster-related pain: a systematic review and meta-analysis. Medicine (Baltimore). 2022;101:e29073. doi: https://doi.org/10.1097/MD.0000000000029073.

  35. Koga R, Yamada K, Ishikawa R, Kubota Y, Yamaguchi K, Iseki M. Association between treatment-related early changes in psychological factors and development of postherpetic neuralgia. J Anesth. 2019;33:636–41. https://doi.org/10.1007/s00540-019-02679-5.

    Article  PubMed  Google Scholar 

Download references

Funding

No external funding was received for the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Department of Anesthesiology, Nara Medical University, 840 Shijocho, Kashihara, Nara, 634-8522, Japan

    Aki Fujiwara, Keisuke Watanabe, Kie Yoshimura, Yuji Yamamura, Mitsuru Ida & Masahiko Kawaguchi

Authors
  1. Aki Fujiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Keisuke Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kie Yoshimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yuji Yamamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mitsuru Ida
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masahiko Kawaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

AF and KW contributed to the study conception and design. AF, KW, KY, and YY contributed to material preparation and data collection. AF and MI performed data analysis. AF wrote the first draft of the manuscript. MK and KW reviewed and edited the manuscript. All authors commented on the previous version of the manuscript. All authors read and approved the final manuscript. This manuscript was edited for English language, grammar, punctuation, and spelling by Editage (https://www.editage.jp/services/english-editing).

Corresponding author

Correspondence to Aki Fujiwara.

Ethics declarations

Conflict of interest

Each author certifies that he or she, or a member of his or her immediate family, has no commercial association (i.e., consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted manuscript.

Ethics approval statement

This retrospective study was approved by the appropriate institutional review board (approval number, 3233; date of approval, February 24, 2022).

Patient consent statement

All eligible patients were allowed to opt out of the study at the Department of Anesthesiology of Nara Medical University website.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fujiwara, A., Watanabe, K., Yoshimura, K. et al. Correlation between pain catastrophizing in acute herpes zoster and postherpetic neuralgia: a retrospective analysis. J Anesth 37, 589–595 (2023). https://doi.org/10.1007/s00540-023-03208-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00540-023-03208-1

Keywords

Search

Navigation