Skip to main content
SpringerLink
Log in

Tolerance to remimazolam at a high effect-site concentration

  • Letter to the Editor
  • Published:
Journal of Anesthesia Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Data availability

The data of this case report are available from the corresponding author upon reasonable request.

References

  1. Yoshikawa H, Hosokawa M, Kashima Y, Oki S, Masui K. Remimazolam tolerance in long-term benzodiazepine users: a case report of 2 cases. A A Pract. 2021;15: e01460.

    Article  Google Scholar 

  2. Miyanishi M, Yaguramaki T, Maehara Y, Nagata O. Three cases of difficulty in achieving definitive loss of consciousness with remimazolam. JA Clin Rep. 2022;8:4.

    Article  Google Scholar 

  3. Masui K, Stöhr T, Pesic M, Tonai T. A population pharmacokinetic model of remimazolam for general anesthesia and consideration of remimazolam dose in clinical practice. J Anesth. 2022;36:493–505.

    Article  Google Scholar 

  4. Masui K, Hagihira S. Equilibration rate constant, ke0, to determine effect-site concentration for the Masui remimazolam population pharmacokinetic model in general anesthesia patients. J Anesth. 2022. https://doi.org/10.1007/s00540-022-03099-8.

    Article  Google Scholar 

  5. Schüttler J, Eisenried A, Lerch M, Fechner J, Jeleazcov C, Ihmsen H. Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: part I pharmacokinetics and clinical pharmacodynamics. Anesthesiology. 2020;132:636–51.

    Article  Google Scholar 

  6. Zhou J, Leonowens C, Ivaturi VD, Lohmer LL, Curd L, Ossig J, Schippers F, Petersen KU, Stoehr T, Schmith V. Population pharmacokinetic/pharmacodynamic modeling for remimazolam in the induction and maintenance of general anesthesia in healthy subjects and in surgical subjects. J Clin Anesth. 2020;66:109899. https://doi.org/10.1016/j.jclinane.2020.109899.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

Funding

None.

Author information

Authors and Affiliations

  1. Department of Anesthesiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan

    Kotaro Kida, Megumi Taguchi, Keita Uchiyama, Shoko Fujioka & Tsunehisa Tsubokawa

Authors
  1. Kotaro Kida
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Megumi Taguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Keita Uchiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shoko Fujioka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tsunehisa Tsubokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MT, KU and TT performed anesthetic management for the patient. SU, KK and TT drafted the manuscript. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Tsunehisa Tsubokawa.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest regarding the publication of this paper.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent for publication

Written informed consent was obtained from the patient for the publication of this case report.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kida, K., Taguchi, M., Uchiyama, K. et al. Tolerance to remimazolam at a high effect-site concentration. J Anesth 37, 168–169 (2023). https://doi.org/10.1007/s00540-022-03139-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00540-022-03139-3

Search

Navigation