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Future liver remnant volume is associated with postoperative fentanyl consumption following open donor hepatectomy: a retrospective multivariate analysis

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Abstract

Purpose

Liver resection has a risk of postoperative hepatic dysfunction, including drug metabolism. Since fentanyl is primarily metabolized in the liver, liver resection requires exercising caution against fentanyl overdose in postoperative analgesia. The rationale for dose adjustment of fentanyl in the preoperative prescription for patients undergoing liver resection remains unclear. We examined whether postoperative fentanyl consumption is associated with the future liver remnant after liver resection and investigated factors influencing fentanyl consumption.

Methods

In this retrospective study, 89 living liver donors undergoing open liver resection received intravenous patient-controlled analgesia with fentanyl 2 mg with thoracic epidural analgesia. The primary outcome was postoperative hourly consumption of intravenous patient-controlled analgesia with fentanyl. Future liver remnant volume (ml) and the ratio of future liver remnant volume to whole liver volume (%) were estimated by computed tomography volumetry and compared to determine which correlated more strongly with fentanyl hourly consumption. Multivariable analysis identified independent factors affecting fentanyl consumption, with adjustments for patient characteristics and intravenous patient-controlled analgesia setting.

Results

Future liver remnant volume (ml) was significantly correlated more strongly than the ratio of future liver remnant (%) with postoperative fentanyl consumption (r = 0.53 vs. 0.36, p < 0.001). Larger future liver remnant volume (β = 0.25, p = 0.006) and age < 45 years (β = 0.24, p = 0.009) were independently associated with higher fentanyl consumption, while sex and weight were not.

Conclusions

Future liver remnant volume was significantly associated with postoperative fentanyl consumption. Smaller remnant liver volume and older age (≥ 45 years) were independent factors reducing postoperative fentanyl consumption in patients undergoing open donor hepatectomy.

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Authors and Affiliations

  1. Department of Anesthesiology, Kumamoto University Hospital, 1-1-1 Honjo Chuo-Ku Kumamoto, Kumamoto, 860-8556, Japan

    Yuri Tsukano, Michiko Sugita, Naoyuki Hirata & Tatsuo Yamamoto

Authors
  1. Yuri Tsukano
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  2. Michiko Sugita
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  3. Naoyuki Hirata
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  4. Tatsuo Yamamoto
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Contributions

YT, MS, and TY contributed to the study conception and design. YT and MS conducted the study, data collection and analysis. NH and TY supervised the study. The first draft of the manuscript was written by YT and all co-authors reviewed and revised the manuscript. All authors read and approved the final manuscript.

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Correspondence to Naoyuki Hirata.

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Tsukano, Y., Sugita, M., Hirata, N. et al. Future liver remnant volume is associated with postoperative fentanyl consumption following open donor hepatectomy: a retrospective multivariate analysis. J Anesth 36, 731–739 (2022). https://doi.org/10.1007/s00540-022-03110-2

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  • DOI: https://doi.org/10.1007/s00540-022-03110-2

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