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Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery

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A Letter to the Editor to this article was published on 11 April 2022

Abstract

Purpose

Postoperative nausea and vomiting (PONV) is a common adverse event after surgery. Remimazolam is a novel sedative agent recently approved for general anesthesia in Japan. This study evaluated the efficacy of remimazolam in the incidence of PONV after laparoscopic gynecological surgery under general anesthesia.

Methods

This prospective, randomized controlled trial included 64 women who underwent laparoscopic gynecological surgery. The patients were randomly assigned to undergo general anesthesia with either remimazolam (REM group) or desflurane (DES group, n = 30, each group). The primary outcome was the incidence of PONV in the two groups at 2 h and 24 h after the surgery. The incidence of vomiting, rescue antiemetic use, and severity of nausea were also evaluated.

Results

In the REM group, the incidence of PONV (27% versus 60%, respectively; P = 0.02), rescue antiemetic use (0 versus 7, respectively; P = 0.01), and nausea score (P = 0.01) were significantly decreased during the first 2 h after surgery. No parameters were significantly different 24 h after surgery between the two groups.

Conclusion

Remimazolam can reduce the incidence of PONV after laparoscopic gynecological surgery compared to general anesthesia with desflurane during the early postoperative period.

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Author information

Author notes

  1. Yuki Hari and Shiho Satomi contributed equally to the authorship of this article.

Authors and Affiliations

  1. Department of Anesthesiology, Tokushima University, 3-18-15, Kuramoto, Tokushima, 770-8503, Japan

    Yuki Hari, Chiaki Murakami, Nami Kakuta & Katsuya Tanaka

  2. Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan

    Shiho Satomi, Soshi Narasaki, Atsushi Morio, Takahiro Kato & Yasuo M. Tsutsumi

Authors
  1. Yuki Hari
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  2. Shiho Satomi
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  3. Chiaki Murakami
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  4. Soshi Narasaki
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  5. Atsushi Morio
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  6. Takahiro Kato
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  7. Yasuo M. Tsutsumi
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  8. Nami Kakuta
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  9. Katsuya Tanaka
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Corresponding author

Correspondence to Nami Kakuta.

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Hari, Y., Satomi, S., Murakami, C. et al. Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery. J Anesth 36, 265–269 (2022). https://doi.org/10.1007/s00540-022-03041-y

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  • DOI: https://doi.org/10.1007/s00540-022-03041-y

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