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Utility of three-dimensional modeling of the fetal airway for ex utero intrapartum treatment

Abstract

Recent technological developments in three-dimensional (3D) printing have created new opportunities for applications in clinical medicine. 3D printing has been adopted for teaching and planning complicated surgeries, including maxillofacial, orthopedic reconstructions, and airway manipulation for one-lung ventilation or airway stenting. We present here the first use of such technology to print a model from in utero imaging for intrapartum treatment planning. A 32-week fetus presented with congenital high airway obstruction syndrome (CHAOS) due to a large cervical lymphatic malformation. An ex utero intrapartum treatment (EXIT) procedure was planned to allow delivery of a viable infant. We printed a 3D model of the fetal airway by printing separate elements: mandible, tongue, mass, larynx, and trachea from the fetal MRI. The elements were stuck together maintaining correct anatomical relationships. Airway planning was then performed in consultation with a pediatric ear nose and throat (ENT) surgeon. 3D modeling in utero presents many challenges: the resolution of the 3D model generated from a fetal MRI is less crisp than from CT images, fetal position may be variable and not in a defined anatomical plane, movement artifact occurs. Nevertheless, pre-procedure simulations with the aid of 3D modeling promoted team cooperation and well-prepared management of the fetus during EXIT.

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References

  1. 1.

    Cassart M, Garel C. European overview of current practice of fetal imaging by pediatric radiologists: a new task force is launched. Pediatr Radiol. 2020;50(12):1794–8.

    Article  Google Scholar 

  2. 2.

    Puricelli MD, Rahbar R, Allen GC, Balakrishnan K, Brigger MT, Daniel SJ, Fayoux P, Goudy S, Hewitt R, Hsu WC, Ida JB, Johnson R, Leboulanger N, Rickert SM, Roy S, Russell J, Rutter M, Sidell D, Soma M, et al. International Pediatric Otolaryngology Group (IPOG): Consensus recommendations on the prenatal and perinatal management of anticipated airway obstruction. Int J Pediatr Otorhinolaryngol. 2020;138:1–10.

    Article  Google Scholar 

  3. 3.

    Laje P, Peranteau WH, Hedrick HL, Flake AW, Johnson MP, Moldenhauer JS, Adzick NS. Ex utero intrapartum treatment (EXIT) in the management of cervical lymphatic malformation. J Pediatr Surg. 2015;50(2):311–4.

    Article  Google Scholar 

  4. 4.

    Liu CC, Huang YC, Yeh PH. Three-dimensional printing technology: an aid for preoperative airway evaluation in patient with situs inversus totalis. J Clin Anesth. 2018;2019(54):55–6.

    Article  Google Scholar 

  5. 5.

    de Kleijn BJ, Kraeima J, Wachters JE, van der Laan BFAM, Wedman J, Witjes MJH, Halmos GB. Virtual 3D planning of tracheostomy placement and clinical applicability of 3D cannula design: a three-step study. Eur Arch Oto-Rhino-Laryngology. 2018;275(2):451–7.

    Article  Google Scholar 

  6. 6.

    Shaylor R, Verenkin V, Golden E, Matot I. The use of three-dimensional printing and virtual reality to develop a personalised airway plan in a 7.5-year-old child: a case report. Eur J Anaesthesiol. 2020;37(6):512–5.

    Article  Google Scholar 

  7. 7.

    Christensen A, Rybicki FJ. Maintaining safety and efficacy for 3D printing in medicine. 3D Print Med. 2017;3(1):1–10.

    Article  Google Scholar 

  8. 8.

    Acr – Sir – Spr Practice Parameter on Informed Consent for Image-Guided Procedures. 2016;1076(Revised 2008):1–8.

  9. 9.

    Tack P, Victor J, Gemmel P, Annemans L. 3D-printing techniques in a medical setting: a systematic literature review. Biomed Eng Online. 2016;15(1):1–21.

    Article  Google Scholar 

  10. 10.

    Fiorelli A, Scaramuzzi R, Minerva I, De Ruberto E, Califano T, Reginelli A, Grassi R, Santini M. Three-dimensional (3D) printed model to plan the endoscopic treatment of upper airway stenosis. J Bronchol Interv Pulmonol. 2018;25(4):349–54.

    Article  Google Scholar 

  11. 11.

    Hong CJ, Giannopoulos AA, Hong BY, Witterick IJ, Irish JC, Lee J, Vescan A, Mitsouras D, Dang W, Campisi P, de Almeida JR, Monteiro E. Clinical applications of three-dimensional printing in otolaryngology–head and neck surgery: a systematic review. Laryngoscope. 2019;129(9):2045–52.

    Article  Google Scholar 

  12. 12.

    Henry CR, Denny AD. Reformatted 3D airway imaging in patients with airway obstruction and micrognathia. J Cranio-Maxillofacial Surg. 2015;43(10):2004–11.

    Article  Google Scholar 

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Acknowledgements

Thanks to Phillip Berman from the Surgical 3D printing Laboratory, Tel-Aviv Medical Center for his assistance in preparing the 3D model.

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Correspondence to Margaret Ekstein.

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Shalev, S., Ben-Sira, L., Wasserzug, O. et al. Utility of three-dimensional modeling of the fetal airway for ex utero intrapartum treatment. J Anesth 35, 595–598 (2021). https://doi.org/10.1007/s00540-021-02950-8

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Keywords

  • Difficult airway
  • Fetus
  • EXIT procedure
  • Three-dimensional model