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Journal of Anesthesia

, Volume 32, Issue 2, pp 250–258 | Cite as

Comparison of propofol and desflurane for postanaesthetic morbidity in patients undergoing surgery for aneurysmal SAH: a randomized clinical trial

  • Avanish Bhardwaj
  • Hemant Bhagat
  • Vinod Kumar Grover
  • Nidhi Bidyut Panda
  • Kiran Jangra
  • Seelora Sahu
  • Navneet Singla
Original Article

Abstract

Purpose

Surgery for aneurysmal clipping after subarachnoid haemorrhage (SAH) poses a unique anaesthetic challenge. However, data on the influence of anaesthetic agents in these patients are lacking. The study aims to evaluate the superiority of propofol over desflurane for postanaesthetic morbidity in patients undergoing surgery following aneurysmal SAH.

Methods

Seventy World Federation of Neurosurgeons Grade I and II patients were randomized into propofol (n = 35) and desflurane groups (n = 35). Anaesthesia was maintained with propofol/fentanyl in propofol group and desflurane/fentanyl in the desflurane group. Jugular venous oxygen saturation (SjVO2) and brain relaxation were assessed intraoperatively. Time to eye opening, response to verbal commands, and extubation were noted from the time of discontinuing the anaesthetic agent. Duration of postoperative hospital stay and modified Rankin score (MRS) at discharge were subsequently compared.

Results

Median postoperative hospital stay was 9 (6, 14) days with use of propofol and 9 (7, 12) days in desflurane group (P = 0.671). 18 patients in the propofol group and 14 patients in the desflurane group had good outcome (modified Rankin score 0–1; P = 0.453). Both the anaesthetics were similar in terms of intraoperative haemodynamics, brain relaxation, time to eye opening, response to verbal commands, and extubation time (P > 0.05). Emergence hypertension was more in the desflurane group (P = 0.007). The intraoperative SjVO2 values were significantly higher in the desflurane group (P < 0.05).

Conclusion

Propofol and desflurane are comparable in terms of postoperative morbidity in patients undergoing aneurysm neck clipping following SAH.

Keywords

Propofol Desflurane Aneurysm Subarachnoid haemorrhage 

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Copyright information

© Japanese Society of Anesthesiologists 2018

Authors and Affiliations

  • Avanish Bhardwaj
    • 1
  • Hemant Bhagat
    • 2
  • Vinod Kumar Grover
    • 2
  • Nidhi Bidyut Panda
    • 2
  • Kiran Jangra
    • 2
  • Seelora Sahu
    • 3
  • Navneet Singla
    • 4
  1. 1.Department of Anaesthesiology and Critical CareCommand Hospital (Airforce)BangaloreIndia
  2. 2.Division of Neuroanaesthesia, Department of Anaesthesia and Intensive CarePost Graduate Institute of Medical Education and ResearchChandigarhIndia
  3. 3.Department of Anaesthesiology and Critical CareTata Main HospitalJamshedpurIndia
  4. 4.Department of NeurosurgeryPost Graduate Institute of Medical Education and ResearchChandigarhIndia

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