Abstract
We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulder persisted for a period of 4 days. The patient also exhibited an episode of severe bradycardia leading to hypotension 7 h after surgery. To our knowledge, this is the first report presenting these adverse events potentially associated with the use of palonosetron.
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Chaw, S.H., Chan, L., Lee, P.K. et al. Prolonged drug-induced myoclonus: is it related to palonosetron?. J Anesth 30, 1063–1066 (2016). https://doi.org/10.1007/s00540-016-2228-8
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DOI: https://doi.org/10.1007/s00540-016-2228-8