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Should anesthesiologists have to confirm effective facemask ventilation before administering the muscle relaxant?

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Abstract

There is ongoing controversy as to whether effective facemask ventilation (FMV) should be established following induction of anesthesia before a muscle relaxant is administered. The rationale for such practice is the belief that, should FMV be ineffective, non-paralyzed patients can be woken up, and subsequently an alternative airway management can be considered. However, the chances of successfully restoring adequate spontaneous respiration before severe hypoxemia develops in an anesthetized, apneic patient who is prone to anesthetic-induced respiratory depression and airway collapse are very small. On the other hand, the overall evidence shows that muscle relaxation is likely to improve or leave unchanged, but not to worsen, the quality of FMV. Furthermore, muscle relaxation will facilitate placement of a supraglottic airway device and endotracheal intubation, interventions which may become essential should the patient become hypoxemic during failed FMV. Thus, the earliest administration of a muscle relaxant following induction of anesthesia may well be the most effective and safest practice. Insistence on demonstration of adequate FMV before administration of a muscle relaxant is more of a ritual than an evidence-based practice. It should therefore be abandoned.

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References

  1. Calder I, Yentis SM. Could ‘safe practice’ be compromising safe practice? Should anaesthetists have to demonstrate that face mask ventilation is possible before giving a neuromuscular blocker? Anaesthesia. 2008;63:113–5.

    Article  CAS  PubMed  Google Scholar 

  2. Xue FS, Liao X, Wang Q, Yuan YJ, Xiong J, Liu JH. Is it unnecessary to confirm successful face mask ventilation before administration of a neuromuscular blocking agent? Anaesthesia. 2011;66:519–20.

    Article  CAS  PubMed  Google Scholar 

  3. Pandit JJ. Checking the ability to mask ventilate before administering long-acting neuromuscular blocking drugs. Anaesthesia. 2011;66:520–2.

    Article  CAS  PubMed  Google Scholar 

  4. Cook T. What about patients whose lungs cannot be ventilated? Anaesthesia. 2011;66:522–3.

    Article  CAS  PubMed  Google Scholar 

  5. Ramachandran SK, Kheterpal S. Difficult mask ventilation: does it matter? Anaesthesia. 2011;66(Suppl. 2):40–4.

    Article  PubMed  Google Scholar 

  6. Richardson MG, Litman RS. Ventilation before paralysis: crossing the Rubicon, slowly. Anesthesiology. 2012;117:456–8.

    Article  PubMed  Google Scholar 

  7. Calder I, Yentis SM. Could ‘safe practice’ be compromising safe practice? Should anaesthetists have to demonstrate that face mask ventilation is possible before giving a neuromuscular blocker? Anaesthesia. 2008;63:113–5.

    Article  CAS  PubMed  Google Scholar 

  8. Priebe H-J. Could ‘safe practice’ be compromising safe practice? Should anaesthetists have to demonstrate that face mask ventilation is possible before giving a neuromuscular blocker? Anaesthesia. 2008;63:671–2.

    Article  PubMed  Google Scholar 

  9. Calder I, Yentis S, Patel A. Muscle relaxants and airway management. Anesthesiology. 2009;111:216–7.

    Article  PubMed  Google Scholar 

  10. Gordon RJ. Anesthesia dogmas and barriers to patient safety? Anesth Analg. 2012;114:694–9.

    Article  PubMed  Google Scholar 

  11. Priebe H-J. Ventilation before paralysis. Anesthesiology. 2013;118:992–3.

    Article  PubMed  Google Scholar 

  12. Broomhead RH, Marks RJ, Ayton P. Confirmation of the ability to ventilate by facemask before administration of neuromuscular blocker: a non-instrumental piece of information? Br J Anaesth. 2010;104:313–7.

    Article  CAS  PubMed  Google Scholar 

  13. Tsuiki S, Isono S, Ishikawa T, Yamashiro Y, Tatsumi K, Nishino T. Anatomical balance of the upper airway and obstructive sleep apnea. Anesthesiology. 2008;108:1009–15.

    Article  PubMed  Google Scholar 

  14. Hajiha M, DuBord MA, Liu H, Horner RL. Opioid receptor mechanisms at the hypoglossal motor pool and effects on tongue muscle activity in vivo. J Physiol. 2009;587:2677–92.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Claeys MA, Camu F. Efficacy of lorazepam and lormetazepam as intravenous premedicants for anesthesia and surgery. Acta Anaesthesiol Belg. 1986;37:113–20.

    CAS  PubMed  Google Scholar 

  16. Eikermann M, Eckert DJ, Chamberlin NL, Jordan AS, Zaremba S, Smith S, Rosow C, Malhotra A. Effects of pentobarbital on upper airway patency during sleep. Eur Respir J. 2010;36:569–76.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Eastwood PR, Szollosi I, Platt PR, Hillman DR. Comparison of upper airway collapse during general anaesthesia and sleep. Lancet. 2002;359:1207–9.

    Article  PubMed  Google Scholar 

  18. Hillman DR, Platt PR, Eastwood PR. The upper airway during anaesthesia. Br J Anaesth. 2003;91:31–9.

    Article  CAS  PubMed  Google Scholar 

  19. Eastwood PR, Platt PR, Shepherd K, Maddison K, Hillman DR. Collapsibility of the upper airway at different concentrations of propofol anesthesia. Anesthesiology. 2005;103:470–7.

    Article  CAS  PubMed  Google Scholar 

  20. Bennett JA, Abrams JT, Van Riper DF, Horrow JC. Difficult or impossible ventilation after sufentanil-induced anesthesia is caused primarily by vocal cord closure. Anesthesiology. 1997;87:1070–4.

    Article  CAS  PubMed  Google Scholar 

  21. Fink BR. The etiology and treatment of laryngeal spasm. Anesthesiology. 1956;17:569–77.

    Article  CAS  PubMed  Google Scholar 

  22. Abrams JT, Horrow JC, Bennett JA, Van Riper D, Storella RJ. Upper airway closure: a primary source of difficult ventilation with sufentanil induction of anesthesia. Anesth Analg. 1996;83:629–32.

    CAS  PubMed  Google Scholar 

  23. Odeh M, Schnall R, Gavriely N, Oliven A. Effect of upper airway muscle contraction on supraglottic resistance and stability. Respir Physiol. 1993;92:139–50.

    Article  CAS  PubMed  Google Scholar 

  24. Isono S, Kochi T, Ide T, Sugimori K, Mizuguchi T, Nishino T. Differential effects of vecuronium on diaphragm and geniohyoid muscle in anaesthetized dogs. Br J Anaesth. 1992;68:239–43.

    Article  CAS  PubMed  Google Scholar 

  25. Warters RD, Szabo TA, Spinale FG, DeSantis SM, Reves JG. The effect of neuromuscular blockade on mask ventilation. Anaesthesia. 2011;66:163–7.

    Article  CAS  PubMed  Google Scholar 

  26. Sachdeva R, Kannan TR, Mendoca C, Patteril M. Evaluation of changes of tidal volume during mask ventilation following administration of neuromuscular blocking drugs. Anaesthesia. 2014;69:826–32.

    Article  CAS  PubMed  Google Scholar 

  27. Pandit JJ, Duncan T, Robbins PA. Total oxygen uptake with two maximal breathing techniques and the tidal volume breathing technique: a physiologic study of preoxygenation. Anesthesiology. 2003;99:841–6.

    Article  PubMed  Google Scholar 

  28. Langeron O, Masso E, Huraux C, Guggiari M, Bianchi A, Coriat P, Riou B. Prediction of difficult mask ventilation. Anesthesiology. 2000;92:1229–36.

    Article  CAS  PubMed  Google Scholar 

  29. Bouvet L, Albert M-L, Augris C, Boselli E, Ecochard R, Rabilloud M, Chassard D, Allaouchiche B. Real-time detection of gastric insufflation related to facemask pressure-controlled ventilation using ultrasonography of the antrum and epigastric auscultation in nonparalyzed patients: a prospective, randomized, double-blind study. Anesthesiology. 2014;120:326–34.

    Article  PubMed  Google Scholar 

  30. Seet MM, Soliman KM, Sbeih ZF. Comparison of three modes of positive pressure mask ventilation during induction of anaesthesia: a prospective, randomized, crossover study. Eur J Anaesthesiol. 2009;26:913–6.

    Article  PubMed  Google Scholar 

  31. Amathieu R, Combes X, Abdi W, Housseini LE, Rezzoug A, Dinca A, Slavov V, Bloc S, Dhonneur G. An algorithm for difficult airway management, modified for modern optical devices (Airtraq laryngoscope; LMA CTrach™): a 2-year prospective validation in patients for elective abdominal, gynecologic, and thyroid surgery. Anesthesiology. 2011;114:25–33.

    Article  PubMed  Google Scholar 

  32. Kheterpal S, Martin L, Shanks AM, Tremper KK. Prediction and outcomes of impossible mask ventilation: a review of 50,000 anesthetics. Anesthesiology. 2009;110:891–7.

    Article  PubMed  Google Scholar 

  33. Goodwin MW, Pandit JJ, Hames K, Popat MT, Yentis SM. The effect of neuromuscular blockade on the efficiency of mask ventilation of the. Anaesthesia. 2003;58:60–3.

    Article  CAS  PubMed  Google Scholar 

  34. Frerk C, Pearce A. Induction and maintenance of anaesthesia. In: Cook T, Woodall N, Frerk C, editors. 4th National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Major Complications of Airway Management in the United Kingdom. London: RCoA; 2011:55-61.

  35. http://www.rcoa.ac.uk/nap4.. Accessed 5 Aug 2015.

  36. Lieutaud T, Billard V, Khalaf H, Debaene B. Muscle relaxation and increasing doses of propofol improve intubating conditions. Can J Anesth. 2003;50:121–6.

    Article  PubMed  Google Scholar 

  37. Combes X, Andriamifidy L, Dufresne E, Suen P, Sauvat S, Scherrer E, Feiss P, Marty J, Duvaldestin P. Comparison of two induction regimens using or not using muscle relaxant: impact on postoperative upper airway discomfort. Br J Anaesth. 2007;99:276–81.

    Article  CAS  PubMed  Google Scholar 

  38. Davis DP, Ochs M, Hoyt DB, Bailey D, Marshall LK, Rosen P. Paramedic-administered neuromuscular blockade improves prehospital intubation success in severely head-injured patients. J Trauma. 2003;55:713–9.

    Article  CAS  PubMed  Google Scholar 

  39. Ramachandran SK, Kheterpal S. Difficult mask ventilation: does it matter? Anaesthesia. 2011;66(Suppl. 2):40–4.

    Article  PubMed  Google Scholar 

  40. Pandit JJ. Checking the ability to mask ventilate before administering long-acting neuromuscular blocking drugs. Anaesthesia. 2011;66:520–2.

    Article  CAS  PubMed  Google Scholar 

  41. Richardson M, Litman R. Ventilation before paralysis: crossing the Rubicon, slowly. Anesthesiology. 2012;117:456–8.

    Article  PubMed  Google Scholar 

  42. Lee C, Jahr JS, Candiotti KA, Warriner B, Zornow MH, Naguib M. Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine. Anesthesiology. 2009;110:1020–5.

    Article  CAS  PubMed  Google Scholar 

  43. Sørensen MK, Bretlau C, Gätke MR, Sørensen AM, Rasmussen LS. Rapid sequence induction and intubation with rocuronium–sugammadex compared with succinylcholine: a randomized trial. Br J Anaesth. 2012;108:682–9.

    Article  PubMed  Google Scholar 

  44. Benumof JL, Dagg R, Benumof R. Critical hemoglobin desaturation will occur before return to an unparalyzed state following 1 mg/kg intravenous succinylcholine. Anesthesiology. 1997;87:979–82.

    Article  CAS  PubMed  Google Scholar 

  45. Ikeda A, Isono S, Sato Y, Yogo H, Sato J, Ishikawa T, Nishino T. Effects of muscle relaxants on mask ventilation in anesthetized persons with normal upper airway anatomy. Anesthesiology. 2012;117:487–93.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Hans-Joachim Priebe.

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Priebe, HJ. Should anesthesiologists have to confirm effective facemask ventilation before administering the muscle relaxant?. J Anesth 30, 132–137 (2016). https://doi.org/10.1007/s00540-015-2072-2

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  • DOI: https://doi.org/10.1007/s00540-015-2072-2

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