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Taurine attenuates lung ischemia–reperfusion injury after lung transplantation in rats

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Taurine, the major intracellular free amino acid found in high concentrations in mammalian cells, is known to be an endogenous antioxidant and a membrane-stabilizing agent. It was hypothesized that taurine may be effective in reducing ischemia–reperfusion injury after lung transplantation and an experimental study was conducted in a rat model.


The number of Sprague–Dawley rats used in the study was 35. Animals were randomized into five groups of 7 rats each, including control, donor I, donor II, ischemia–reperfusion injury, and treatment groups. All animals were exposed to the same experimental conditions in the preoperative period. Rats were fixed in a supine position after the induction. After the rats were shaved, a left pneumonectomy was performed following sternotomy in control, donor I, and donor II groups. The harvested grafts in donor I and donor II groups were transplanted to the rats of the ischemia–reperfusion group and treatment group, respectively. However, taurine was administered intraperitoneally for 3 days before the harvesting procedure in donor II. All harvested lungs were kept in a Euro-Collins solution at +4 °C for 24 h in a half-inflated manner. After harvesting and transplantation, lungs were sampled for histopathological and biochemical analysis.


Malondialdehyde and superoxide dismutase, glutathione peroxidase, and catalase levels were lower in the treatment group than the other groups (p < 0.05). Histopathological findings were better in treatment group than the ischemia–reperfusion group (p < 0.05).


It was demonstrated that donor treatment with taurine resulted in preservation of transplanted lung tissue in respect to histopathological and biochemical findings.

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Leyla Guler, Murat Tavlasoglu, Orhan Yücel, Adem Güler, and Mehmet Ali Sahin contributed to the pre-operative and operative planning of the groups, and performed the surgical procedures. Mustafa Kurkluoglu, Yusuf Sirin, Ayse Eken, Mehmet Gamsizkan, Mehmet Dakak, Sedat Gurkok, and Onur Genc recorded and analyzed follow-up data. All authors read and approved the final version of manuscript.

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Correspondence to Murat Tavlasoglu.

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Guler, L., Tavlasoglu, M., Yucel, O. et al. Taurine attenuates lung ischemia–reperfusion injury after lung transplantation in rats. J Anesth 28, 347–353 (2014).

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