Skip to main content
Log in

Effects of oxidative stress on vascular function, and the role of anesthetics

  • JA Symposium
  • Published:
Journal of Anesthesia Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Chrissobolis S, Faraci FM. The role of oxidative stress and NADPH oxidase in cerebrovascular disease. Trends Mol Med. 2008;14:495–502.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Faraci FM. Reactive oxygen species: influence on cerebral vascular tone. J Appl Physiol. 2006;100:739–43.

    Article  CAS  PubMed  Google Scholar 

  3. Clempus RE, Griendling KK. Reactive oxygen species signaling in vascular smooth muscle cells. Cardiovasc Res. 2006;71:216–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bedard K, Krause K-H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87:245–313.

    Article  CAS  PubMed  Google Scholar 

  5. Schulz E, Münzel T. NOX5, a new “radical” player in human atherosclerosis? J Am Coll Cardiol. 2008;52:1810–2.

    Article  CAS  PubMed  Google Scholar 

  6. Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, Pagano PJ, Schiffrin EL. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II. Circ Res. 2002;90:1205–13.

    Article  CAS  PubMed  Google Scholar 

  7. Kinoshita H, Matsuda N, Kaba H, Hatakeyama N, Azma T, Nakahata K, Kuroda Y, Tange K, Iranami H, Hatano Y. Roles of phosphatidylinositol 3-kinase-Akt and NADPH oxidase in adenosine 5′-triphosphate-sensitive K+ channel function impaired by high glucose in the human artery. Hypertension. 2008;52:507–13.

    Article  CAS  PubMed  Google Scholar 

  8. Dworakowski R, Walker S, Momin A, Desai J, El-Gamel A, Wendler O, Kearney MT, Shah AM. Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure. J Am Coll Cardiol. 2008;51:1349–56.

    Article  CAS  PubMed  Google Scholar 

  9. Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, Gates PE, Seals DR. Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47phox expression and evidence of endothelial oxidative stress. Circulation. 2007;115:627–37.

    Article  CAS  PubMed  Google Scholar 

  10. Haba M, Kinoshita H, Matsuda N, Azma T, Hama-Tomioka K, Hatakeyama N, Yamazaki M, Hatano Y. Beneficial effect of propofol on arterial adenosine triphosphate-sensitive K+ channel function impaired by thromboxane. Anesthesiology. 2009;111:279–86.

    Article  CAS  PubMed  Google Scholar 

  11. Nakahata K, Kinoshita H, Azma T, Matsuda N, Hama-Tomioka K, Haba M, Hatano Y. Propofol restores brain microvascular function impaired by high glucose via the decrease in oxidative stress. Anesthesiology. 2008;108:269–75.

    Article  CAS  PubMed  Google Scholar 

  12. Hama-Tomioka K, Kinoshita H, Azma T, Nakahata K, Matsuda N, Hatakeyama N, Kikuchi H, Hatano Y. The role of 20-hydroxyeicosatetraenoic acid in cerebral arteriolar constriction and the inhibitory effect of propofol. Anesth Analg. 2009;109:1935–42.

    Article  CAS  PubMed  Google Scholar 

  13. Lam C-F, Liu Y-C, Tseng F-L, Sung Y-H, Huang C–C, Jiang M-J, Tsai Y-C. High-dose morphine impairs vascular endothelial function by increased production of superoxide anions. Anesthesiology. 2007;106:532–7.

    Article  CAS  PubMed  Google Scholar 

  14. Myles PS, Chan MTV, Kaye DM, Mcllroy DR, Lau C-W, Symons JA, Chen S. Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function. Anesthesiology. 2008;109:657–63.

    Article  CAS  PubMed  Google Scholar 

  15. Ungvari Z, Csiszar A, Edwards JG, Kaminski PM, Wolin MS, Kaley G, Koller A. Increased superoxide production in coronary arteries in hyperhomocysteinemia: Role of tumor necrosis factor-α, NAD(P)H oxidase, and inducible nitric oxide synthase. Arterioscler Thromb Vasc Biol. 2003;23:418–24.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hiroyuki Kinoshita.

About this article

Cite this article

Kinoshita, H. Effects of oxidative stress on vascular function, and the role of anesthetics. J Anesth 26, 141–142 (2012). https://doi.org/10.1007/s00540-011-1283-4

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00540-011-1283-4

Keywords

Navigation