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Back massage therapy promotes psychological relaxation and an increase in salivary chromogranin A release

Journal of Anesthesia volume 24, pages 955–958 (2010)Cite this article

Abstract

Massage therapy promotes psychosocial relaxation, reduces stress and has been reported to improve the immune function. As such, massage therapy is currently used in palliative care for the relief of anxiety and pain. Although psychosocial status has been evaluated using subjective psychological tests, such as State-Trait Anxiety Inventory (STAI), subjective psychological tests are of limited value if the subjects fail to report reliably. Salivary biomarkers have been recently suggested as useful objective markers for assessing psychosocial status. To determine whether salivary biomarkers are useful objective indices for assessing the effects of back massage on the mental status of 25 young healthy female volunteers, we measured heart rate and salivary biomarkers (α-amylase activity, cortisol, and chromogranin A) and assessed the STAI score before and after the back massage. Back massage significantly reduced the heart rate and STAI; however, salivary amylase and cortisol levels did not change. In contrast, the level of salivary chromogranin A significantly increased. We therefore conclude that changes in the salivary biomarkers tested here may not indicate changes in psychological status following massage therapy. However, the increase in chromogranin A release may contribute to the immunologically beneficial effects of massage therapy as chromogranin A has antibacterial and antifungal activity.

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References

  1. Field TM. Massage therapy effects. Am Psychol. 1998;53:1270–81.

    CAS  PubMed  Article  Google Scholar 

  2. Goodfellow LM. The effects of therapeutic back massage on psychophysiologic variables and immune function in spouses of patients with cancer. Nurs Res. 2003;52:318–28.

    PubMed  Article  Google Scholar 

  3. Smith MC, Yamashita TE, Bryant LL, Hemphill L, Kutner JS. Providing massage therapy for people with advanced cancer: what to expect. J Altern Complement Med. 2009;15:367–71.

    PubMed  Article  Google Scholar 

  4. Nakane H, Asami O, Yamada Y, Ohira H. Effect of negative air ions on computer operation, anxiety and salivary chromogranin A-like immunoreactivity. Int J Psychophysiol. 2002;46:85–9.

    PubMed  Article  Google Scholar 

  5. Kirschbaum C, Hellhammer DH. Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology. 1994;19:313–33.

    CAS  PubMed  Article  Google Scholar 

  6. Chatterton RT Jr, Vogelsong KM, Lu YC, Ellman AB, Hudgens GA. Salivary alpha-amylase as a measure of endogenous adrenergic activity. Clin Physiol. 1996;16:433–48.

    CAS  PubMed  Article  Google Scholar 

  7. Kanamaru Y, Kikukawa A, Shimamura K. Salivary chromogranin-A as a marker of psychological stress during a cognitive test battery in humans. Stress. 2006;9:127–31.

    CAS  PubMed  Article  Google Scholar 

  8. Noto Y, Sato T, Kudo M, Kurata K, Hirota K. The relationship between salivary biomarkers and state-trait anxiety inventory score under mental arithmetic stress: a pilot study. Anesth Analg. 2005;101:1873–6.

    CAS  PubMed  Article  Google Scholar 

  9. Shirasaki S, Fujii H, Takahashi M, Sato T, Ebina M, Noto Y, Hirota K. Correlation between salivary alpha-amylase activity and pain scale in patients with chronic pain. Reg Anesth Pain Med. 2007;32:120–3.

    CAS  PubMed  Google Scholar 

  10. Takiyyuddin MA, Brown MR, Dinh TQ, Cervenka JH, Braun SD, Parmer RJ, Kennedy B, O’Connor DT. Sympatho-adrenal secretion in humans: factors governing catecholamine and storage vesicle peptide co-release. J Auton Pharmacol. 1994;14:187–200.

    CAS  PubMed  Article  Google Scholar 

  11. Rohleder N, Nater UM, Wolf JM, Ehlert U, Kirschbaum C. Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity? Ann NY Acad Sci. 2004;1032:258–63.

    CAS  PubMed  Article  Google Scholar 

  12. Kanno T, Asada N, Yanase H, Iwanaga T, Ozaki T, Nishikawa Y, Iguchi K, Mochizuki T, Hoshino M, Yanaihara N. Salivary secretion of highly concentrated chromogranin a in response to noradrenaline and acetylcholine in isolated and perfused rat submandibular glands. Exp Physiol. 1999;84:1073–83.

    CAS  PubMed  Article  Google Scholar 

  13. Diego MA, Field T, Hernandez-Reif M, Shaw K, Friedman L, Ironson G. HIV adolescents show improved immune function following massage therapy. Int J Neurosci. 2001;106:35–45.

    CAS  PubMed  Article  Google Scholar 

  14. Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH. Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A. J Biol Chem. 2000;275:10745–53.

    CAS  PubMed  Article  Google Scholar 

  15. Metz-Boutigue MH, Goumon Y, Strub JM, Lugardon K, Aunis D. Antimicrobial chromogranins and proenkephalin-A-derived peptides: Antibacterial and antifungal activities of chromogranins and proenkephalin-A-derived peptides. Ann NY Acad Sci. 2003;992:168–78.

    CAS  PubMed  Article  Google Scholar 

  16. Ring C, Carroll D, Hoving J, Ormerod J, Harrison LK, Drayson M. Effects of competition, exercise, and mental stress on secretory immunity. J Sports Sci. 2005;23:501–8.

    PubMed  Article  Google Scholar 

  17. Groër M, Mozingo J, Droppleman P, Davis M, Jolly ML, Boynton M, Davis K, Kay S. Measures of salivary secretory immunoglobulin A and state anxiety after a nursing back rub. Appl Nurs Res. 1994;7:2–6.

    PubMed  Article  Google Scholar 

  18. Marcotte H, Lavoie MC. Oral microbial ecology and the role of salivary immunoglobulin A. Microbiol Mol Biol Rev. 1998;62:71–109.

    CAS  PubMed  Google Scholar 

  19. Duggan M, Dowd N, O’Mara D, Harmon D, Tormey W, Cunningham AJ. Benzodiazepine premedication may attenuate the stress response in daycase anesthesia: a pilot study. Can J Anaesth. 2002;49:932–5.

    PubMed  Article  Google Scholar 

  20. Arai YC, Sakakibara S, Ito A, Ohshima K, Sakakibara T, Nishi T, Hibino S, Niwa S, Kuniyoshi K. Intra-operative natural sound decreases salivary amylase activity of patients undergoing inguinal hernia repair under epidural anesthesia. Acta Anaesthesiol Scand. 2008;52:987–90.

    CAS  PubMed  Article  Google Scholar 

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Acknowledgments

The authors thank Dr. DG Lambert (University Department of Cardiovascular Sciences (Pharmacology and Therapeutics Group), Division of Anaesthesia, Critical Care and Pain Management, Leicester Royal infirmary, UK) for his valuable comments.

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Authors and Affiliations

  1. Department of Nursing, Hirosaki University Graduate School of Health Sciences, Hirosaki, 036-8563, Japan

    Yuka Noto

  2. Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8563, Japan

    Mihoko Kudo & Kazuyoshi Hirota

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  1. Yuka Noto
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  2. Mihoko Kudo
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  3. Kazuyoshi Hirota
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Correspondence to Kazuyoshi Hirota.

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Noto, Y., Kudo, M. & Hirota, K. Back massage therapy promotes psychological relaxation and an increase in salivary chromogranin A release. J Anesth 24, 955–958 (2010). https://doi.org/10.1007/s00540-010-1001-7

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  • DOI: https://doi.org/10.1007/s00540-010-1001-7

Keywords

  • Mental stress
  • State-Trait Anxiety Inventory score
  • Massage therapy
  • Salivary chromogranin A