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Effects of landiolol on left ventricular function during electroconvulsive therapy: a transthoracic echocardiographic study

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Abstract

The purpose of this study was to examine the effects of landiolol on left ventricular (LV) systolic function, using transthoracic echocardiography, during electroconvulsive therapy (ECT). Fourteen patients undergoing ECT were studied. Bilateral ECT was performed after administration of thiopentone (2 mg/kg), succinylcholine (1 mg/kg), and initiation of assisted mask ventilation with 100% oxygen. Patients received a bolus injection of landiolol (0.125 mg/kg) or saline immediately after anesthetic induction and prior to electrical shock. LV systolic function was examined by transthoracic echocardiography prior to anesthetic induction, throughout the ECT procedure, and for 10 min after the seizure. Electrical shock resulted in a significant decrease in fractional area change (FAC) when compared with the awake condition in the control group [FAC when awake: 48 ± 3%; 1 min after ECT: 38 ± 4%*; 2 min after ECT: 36 ± 4%*; 3 min after ECT: 40 ± 3%*; mean ± standard deviation, *p < 0.05 compared with awake]. Landiolol infusion stabilized systemic hemodynamics and LV systolic function. The study demonstrated that landiolol is a suitable agent to minimize hemodynamic changes and transthoracic echocardiographic variability after ECT.

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Acknowledgments

The authors thank Forte, Inc. (Tokyo, Japan) for reviewing English syntax and grammar. This study was supported by grants (to Dr. Kadoi, #21591998) from the Japanese Ministry of Science, Education and Culture.

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Authors and Affiliations

  1. Department of Anesthesiology, Gunma University Hospital, School of Medicine, 3-39-22 Showa-Machi, Maebashi, Gunma, 371-8511, Japan

    Masanobu Ide, Yuji Kadoi & Shigeru Saito

  2. Department of Anesthesia, Ashikaga Red Cross Hospital, Ashikaga, Japan

    Kenichiro Takahashi

  3. Department of Anesthesia, Tomioka General Hospital, Tomioka, Japan

    Yukari Sawano, Masumi Miyazaki & Hitoshi Shimada

Authors
  1. Masanobu Ide
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  2. Yuji Kadoi
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  3. Shigeru Saito
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  4. Kenichiro Takahashi
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  5. Yukari Sawano
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  6. Masumi Miyazaki
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  7. Hitoshi Shimada
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Correspondence to Yuji Kadoi.

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Ide, M., Kadoi, Y., Saito, S. et al. Effects of landiolol on left ventricular function during electroconvulsive therapy: a transthoracic echocardiographic study. J Anesth 24, 272–276 (2010). https://doi.org/10.1007/s00540-010-0870-0

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  • DOI: https://doi.org/10.1007/s00540-010-0870-0

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